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Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms
Baroreflex sensitivity (BRS) is a measure of cardiovagal baroreflex and is lower in normobaric and hypobaric hypoxia compared to normobaric normoxia. The aim of this study was to assess the effects of hypobaria on BRS in normoxia and hypoxia. Continuous blood pressure and ventilation were recorded i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Georg Thieme Verlag
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977572/ https://www.ncbi.nlm.nih.gov/pubmed/36455595 http://dx.doi.org/10.1055/a-1960-3407 |
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author | Bourdillon, Nicolas Aebi, Mathias Rolland Kayser, Bengt Bron, Denis Millet, Gregoire P |
author_facet | Bourdillon, Nicolas Aebi, Mathias Rolland Kayser, Bengt Bron, Denis Millet, Gregoire P |
author_sort | Bourdillon, Nicolas |
collection | PubMed |
description | Baroreflex sensitivity (BRS) is a measure of cardiovagal baroreflex and is lower in normobaric and hypobaric hypoxia compared to normobaric normoxia. The aim of this study was to assess the effects of hypobaria on BRS in normoxia and hypoxia. Continuous blood pressure and ventilation were recorded in eighteen seated participants in normobaric normoxia (NNx), hypobaric normoxia (HNx), normobaric hypoxia (NHx) and hypobaric hypoxia (HHx). Barometric pressure was matched between NNx vs. NHx (723±4 mmHg) and HNx vs. HHx (406±4 vs. 403±5 mmHg). Inspired oxygen pressure (PiO (2) ) was matched between NNx vs. HNx (141.2±0.8 vs. 141.5±1.5 mmHg) and NHx vs. HHx (75.7±0.4 vs. 74.3±1.0 mmHg). BRS was assessed using the sequence method. BRS significantly decreased in HNx, NHx and HHx compared to NNx. Heart rate, mean systolic and diastolic blood pressures did not differ between conditions. There was the specific effect of hypobaria on BRS in normoxia (BRS was lower in HNx than in NNx). The hypoxic and hypobaric effects do not add to each other resulting in comparable BRS decreases in HNx, NHx and HHx. BRS decrease under low barometric pressure requires future studies independently controlling O (2) and CO (2) to identify central and peripheral chemoreceptors’ roles. |
format | Online Article Text |
id | pubmed-9977572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Georg Thieme Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-99775722023-03-02 Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms Bourdillon, Nicolas Aebi, Mathias Rolland Kayser, Bengt Bron, Denis Millet, Gregoire P Int J Sports Med Baroreflex sensitivity (BRS) is a measure of cardiovagal baroreflex and is lower in normobaric and hypobaric hypoxia compared to normobaric normoxia. The aim of this study was to assess the effects of hypobaria on BRS in normoxia and hypoxia. Continuous blood pressure and ventilation were recorded in eighteen seated participants in normobaric normoxia (NNx), hypobaric normoxia (HNx), normobaric hypoxia (NHx) and hypobaric hypoxia (HHx). Barometric pressure was matched between NNx vs. NHx (723±4 mmHg) and HNx vs. HHx (406±4 vs. 403±5 mmHg). Inspired oxygen pressure (PiO (2) ) was matched between NNx vs. HNx (141.2±0.8 vs. 141.5±1.5 mmHg) and NHx vs. HHx (75.7±0.4 vs. 74.3±1.0 mmHg). BRS was assessed using the sequence method. BRS significantly decreased in HNx, NHx and HHx compared to NNx. Heart rate, mean systolic and diastolic blood pressures did not differ between conditions. There was the specific effect of hypobaria on BRS in normoxia (BRS was lower in HNx than in NNx). The hypoxic and hypobaric effects do not add to each other resulting in comparable BRS decreases in HNx, NHx and HHx. BRS decrease under low barometric pressure requires future studies independently controlling O (2) and CO (2) to identify central and peripheral chemoreceptors’ roles. Georg Thieme Verlag 2022-12-01 /pmc/articles/PMC9977572/ /pubmed/36455595 http://dx.doi.org/10.1055/a-1960-3407 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Bourdillon, Nicolas Aebi, Mathias Rolland Kayser, Bengt Bron, Denis Millet, Gregoire P Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms |
title | Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through
Different Mechanisms |
title_full | Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through
Different Mechanisms |
title_fullStr | Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through
Different Mechanisms |
title_full_unstemmed | Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through
Different Mechanisms |
title_short | Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through
Different Mechanisms |
title_sort | both hypoxia and hypobaria impair baroreflex sensitivity but through
different mechanisms |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977572/ https://www.ncbi.nlm.nih.gov/pubmed/36455595 http://dx.doi.org/10.1055/a-1960-3407 |
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