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Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España

OBJECTIVE: To analyze the impact of the COVID-19 pandemic on the diagnosis and management of uveal melanoma (a tumor included in the Orphanet catalog of rare diseases) in a Spanish national reference unit for intraocular tumors during the first year of the pandemic. MATERIAL AND METHODS: An observat...

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Autores principales: Bermúdez Castellanos, I., Saornil Álvarez, M.A., Almaraz Gómez, A., Villoría Díaz, S., García Álvarez, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977621/
https://www.ncbi.nlm.nih.gov/pubmed/37122608
http://dx.doi.org/10.1016/j.oftal.2023.01.010
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author Bermúdez Castellanos, I.
Saornil Álvarez, M.A.
Almaraz Gómez, A.
Villoría Díaz, S.
García Álvarez, C.
author_facet Bermúdez Castellanos, I.
Saornil Álvarez, M.A.
Almaraz Gómez, A.
Villoría Díaz, S.
García Álvarez, C.
author_sort Bermúdez Castellanos, I.
collection PubMed
description OBJECTIVE: To analyze the impact of the COVID-19 pandemic on the diagnosis and management of uveal melanoma (a tumor included in the Orphanet catalog of rare diseases) in a Spanish national reference unit for intraocular tumors during the first year of the pandemic. MATERIAL AND METHODS: An observational retrospective study of patients with uveal melanoma in the National Reference Unit for Adult Intraocular Tumors of the Hospital Clínico Universitario de Valladolid (Spain) was performed, analyzing the pre- and post-COVID-19 periods: from March 15, 2019 to March 15, 2020 and from March 16, 2020 to March 16, 2021. Demographic data, diagnostic delay, tumor size, extraocular extension, treatment and evolution were collected. A multivariable logistic regression model was used to identify factors that were associated with the variable: enucleation. RESULTS: Eighty-two patients with uveal melanoma were included, of which 42(51.21%) belonged to the pre-COVID-19 period and 40(40.78%) to the post-COVID-19 period. An increase in tumor size at diagnosis and in the number of enucleations was observed during the post-COVID-19 period (p < 0.05). Multivariable logistic regression demonstrated that both medium-large tumor size and patients diagnosed in the post-COVID-19 period were independently related to an increased risk of enucleation (OR 250, 95%CI, 27.69-2256.37; p < 0.01 and OR 10; 95% CI,1.10-90.25; p = 0.04, respectively). CONCLUSIONS: The increase in tumor size observed in uveal melanomas diagnosed during the first year of the COVID-19 pandemic may have favored the increase in the number of enucleations performed during that period.
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spelling pubmed-99776212023-03-02 Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España Bermúdez Castellanos, I. Saornil Álvarez, M.A. Almaraz Gómez, A. Villoría Díaz, S. García Álvarez, C. Arch Soc Esp Oftalmol Artículo Original OBJECTIVE: To analyze the impact of the COVID-19 pandemic on the diagnosis and management of uveal melanoma (a tumor included in the Orphanet catalog of rare diseases) in a Spanish national reference unit for intraocular tumors during the first year of the pandemic. MATERIAL AND METHODS: An observational retrospective study of patients with uveal melanoma in the National Reference Unit for Adult Intraocular Tumors of the Hospital Clínico Universitario de Valladolid (Spain) was performed, analyzing the pre- and post-COVID-19 periods: from March 15, 2019 to March 15, 2020 and from March 16, 2020 to March 16, 2021. Demographic data, diagnostic delay, tumor size, extraocular extension, treatment and evolution were collected. A multivariable logistic regression model was used to identify factors that were associated with the variable: enucleation. RESULTS: Eighty-two patients with uveal melanoma were included, of which 42(51.21%) belonged to the pre-COVID-19 period and 40(40.78%) to the post-COVID-19 period. An increase in tumor size at diagnosis and in the number of enucleations was observed during the post-COVID-19 period (p < 0.05). Multivariable logistic regression demonstrated that both medium-large tumor size and patients diagnosed in the post-COVID-19 period were independently related to an increased risk of enucleation (OR 250, 95%CI, 27.69-2256.37; p < 0.01 and OR 10; 95% CI,1.10-90.25; p = 0.04, respectively). CONCLUSIONS: The increase in tumor size observed in uveal melanomas diagnosed during the first year of the COVID-19 pandemic may have favored the increase in the number of enucleations performed during that period. Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. 2023-05 2023-03-02 /pmc/articles/PMC9977621/ /pubmed/37122608 http://dx.doi.org/10.1016/j.oftal.2023.01.010 Text en © 2023 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Artículo Original
Bermúdez Castellanos, I.
Saornil Álvarez, M.A.
Almaraz Gómez, A.
Villoría Díaz, S.
García Álvarez, C.
Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España
title Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España
title_full Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España
title_fullStr Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España
title_full_unstemmed Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España
title_short Impacto del COVID-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en España
title_sort impacto del covid-19 en una enfermedad rara (melanoma uveal) en una unidad de referencia nacional de tumores intraoculares en españa
topic Artículo Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977621/
https://www.ncbi.nlm.nih.gov/pubmed/37122608
http://dx.doi.org/10.1016/j.oftal.2023.01.010
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