A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals

By endowing light control of neuronal activity, optogenetics and photopharmacology are powerful methods notably used to probe the transmission of pain signals. However, costs, animal handling and ethical issues have reduced their dissemination and routine use. Here we report LAKI (Light Activated K(...

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Detalles Bibliográficos
Autores principales: Landra-Willm, Arnaud, Karapurkar, Ameya, Duveau, Alexia, Chassot, Anne Amandine, Esnault, Lucille, Callejo, Gerard, Bied, Marion, Häfner, Stephanie, Lesage, Florian, Wdziekonski, Brigitte, Baron, Anne, Fossat, Pascal, Marsollier, Laurent, Gasull, Xavier, Boué-Grabot, Eric, Kienzler, Michael A., Sandoz, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977718/
https://www.ncbi.nlm.nih.gov/pubmed/36859433
http://dx.doi.org/10.1038/s41467-023-36806-4

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