Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells

The selective transport to lysosomes can be mediated by either mannose-6-phosphate receptors (CD-MPR and CI-MPR) or sortilin. In mammalian epididymis, some lysosomal proteins are secreted into the lumen through unknown mechanisms. To investigate the underlying mechanisms of lysosomal protein transpo...

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Detalles Bibliográficos
Autores principales: Aguilera, Andrea Carolina, Leiva, Natalia, Alvarez, Pablo Ariel, Pulcini, Georgina, Pereyra, Laura Lucía, Morales, Carlos Ramón, Sosa, Miguel Ángel, Carvelli, Lorena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977780/
https://www.ncbi.nlm.nih.gov/pubmed/36859404
http://dx.doi.org/10.1038/s41598-023-29157-z

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