Cargando…

Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation

Fungal exposure and sensitization negatively affect outcomes in various respiratory diseases, however, the effect of fungal sensitization in lung transplant (LTx) recipients is still unknown. We performed a retrospective cohort study of prospectively collected data on circulating fungal specific IgG...

Descripción completa

Detalles Bibliográficos
Autores principales: Beeckmans, Hanne, Van Roy, Elfri, Kaes, Janne, Sacreas, Annelore, Geudens, Vincent, Vermaut, Astrid, Willems, Lynn, Jin, Xin, Bos, Saskia, Vanstapel, Arno, Van Slambrouck, Jan, Orlitova, Michaela, Vanaudenaerde, Bart, Ceulemans, Laurens J., Van Raemdonck, Dirk, Neyrinck, Arne P., Godinas, Laurent, Dupont, Lieven J., Verleden, Geert M., Vos, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977785/
https://www.ncbi.nlm.nih.gov/pubmed/36873745
http://dx.doi.org/10.3389/ti.2023.10768
_version_ 1784899369858760704
author Beeckmans, Hanne
Van Roy, Elfri
Kaes, Janne
Sacreas, Annelore
Geudens, Vincent
Vermaut, Astrid
Willems, Lynn
Jin, Xin
Bos, Saskia
Vanstapel, Arno
Van Slambrouck, Jan
Orlitova, Michaela
Vanaudenaerde, Bart
Ceulemans, Laurens J.
Van Raemdonck, Dirk
Neyrinck, Arne P.
Godinas, Laurent
Dupont, Lieven J.
Verleden, Geert M.
Vos, Robin
author_facet Beeckmans, Hanne
Van Roy, Elfri
Kaes, Janne
Sacreas, Annelore
Geudens, Vincent
Vermaut, Astrid
Willems, Lynn
Jin, Xin
Bos, Saskia
Vanstapel, Arno
Van Slambrouck, Jan
Orlitova, Michaela
Vanaudenaerde, Bart
Ceulemans, Laurens J.
Van Raemdonck, Dirk
Neyrinck, Arne P.
Godinas, Laurent
Dupont, Lieven J.
Verleden, Geert M.
Vos, Robin
author_sort Beeckmans, Hanne
collection PubMed
description Fungal exposure and sensitization negatively affect outcomes in various respiratory diseases, however, the effect of fungal sensitization in lung transplant (LTx) recipients is still unknown. We performed a retrospective cohort study of prospectively collected data on circulating fungal specific IgG/IgE antibodies, and their correlation with fungal isolation, chronic lung allograft dysfunction (CLAD) and overall survival after LTx. 311 patients transplanted between 2014 and 2019 were included. Patients with elevated Aspergillus fumigatus or Aspergillus flavus IgG (10%) had more mold and Aspergillus species isolation (p = 0.0068 and p = 0.0047). Aspergillus fumigatus IgG was specifically associated with Aspergillus fumigatus isolation in the previous or consecutive year (AUC 0.60, p = 0.004 and AUC 0.63, p = 0.022, respectively). Elevated Aspergillus fumigatus or Aspergillus flavus IgG was associated with CLAD (p = 0.0355), but not with death. Aspergillus fumigatus, Aspergillus flavus or Aspergillus niger IgE was elevated in 19.3% of patients, but not associated with fungal isolation, CLAD or death. Mold isolation and Aspergillus species isolation from respiratory cultures were associated with CLAD occurrence (p = 0.0011 and p = 0.0005, respectively), and Aspergillus species isolation was also associated with impaired survival (p = 0.0424). Fungus-specific IgG could be useful in long-term follow-up post-LTx, as a non-invasive marker for fungal exposure, and thus a diagnostic tool for identifying patients at risk for fungal-related complications and CLAD.
format Online
Article
Text
id pubmed-9977785
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99777852023-03-03 Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation Beeckmans, Hanne Van Roy, Elfri Kaes, Janne Sacreas, Annelore Geudens, Vincent Vermaut, Astrid Willems, Lynn Jin, Xin Bos, Saskia Vanstapel, Arno Van Slambrouck, Jan Orlitova, Michaela Vanaudenaerde, Bart Ceulemans, Laurens J. Van Raemdonck, Dirk Neyrinck, Arne P. Godinas, Laurent Dupont, Lieven J. Verleden, Geert M. Vos, Robin Transpl Int Health Archive Fungal exposure and sensitization negatively affect outcomes in various respiratory diseases, however, the effect of fungal sensitization in lung transplant (LTx) recipients is still unknown. We performed a retrospective cohort study of prospectively collected data on circulating fungal specific IgG/IgE antibodies, and their correlation with fungal isolation, chronic lung allograft dysfunction (CLAD) and overall survival after LTx. 311 patients transplanted between 2014 and 2019 were included. Patients with elevated Aspergillus fumigatus or Aspergillus flavus IgG (10%) had more mold and Aspergillus species isolation (p = 0.0068 and p = 0.0047). Aspergillus fumigatus IgG was specifically associated with Aspergillus fumigatus isolation in the previous or consecutive year (AUC 0.60, p = 0.004 and AUC 0.63, p = 0.022, respectively). Elevated Aspergillus fumigatus or Aspergillus flavus IgG was associated with CLAD (p = 0.0355), but not with death. Aspergillus fumigatus, Aspergillus flavus or Aspergillus niger IgE was elevated in 19.3% of patients, but not associated with fungal isolation, CLAD or death. Mold isolation and Aspergillus species isolation from respiratory cultures were associated with CLAD occurrence (p = 0.0011 and p = 0.0005, respectively), and Aspergillus species isolation was also associated with impaired survival (p = 0.0424). Fungus-specific IgG could be useful in long-term follow-up post-LTx, as a non-invasive marker for fungal exposure, and thus a diagnostic tool for identifying patients at risk for fungal-related complications and CLAD. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9977785/ /pubmed/36873745 http://dx.doi.org/10.3389/ti.2023.10768 Text en Copyright © 2023 Beeckmans, Van Roy, Kaes, Sacreas, Geudens, Vermaut, Willems, Jin, Bos, Vanstapel, Van Slambrouck, Orlitova, Vanaudenaerde, Ceulemans, Van Raemdonck, Neyrinck, Godinas, Dupont, Verleden and Vos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Beeckmans, Hanne
Van Roy, Elfri
Kaes, Janne
Sacreas, Annelore
Geudens, Vincent
Vermaut, Astrid
Willems, Lynn
Jin, Xin
Bos, Saskia
Vanstapel, Arno
Van Slambrouck, Jan
Orlitova, Michaela
Vanaudenaerde, Bart
Ceulemans, Laurens J.
Van Raemdonck, Dirk
Neyrinck, Arne P.
Godinas, Laurent
Dupont, Lieven J.
Verleden, Geert M.
Vos, Robin
Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation
title Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation
title_full Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation
title_fullStr Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation
title_full_unstemmed Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation
title_short Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation
title_sort aspergillus-specific igg antibodies are associated with fungal-related complications and chronic lung allograft dysfunction after lung transplantation
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977785/
https://www.ncbi.nlm.nih.gov/pubmed/36873745
http://dx.doi.org/10.3389/ti.2023.10768
work_keys_str_mv AT beeckmanshanne aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT vanroyelfri aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT kaesjanne aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT sacreasannelore aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT geudensvincent aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT vermautastrid aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT willemslynn aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT jinxin aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT bossaskia aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT vanstapelarno aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT vanslambrouckjan aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT orlitovamichaela aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT vanaudenaerdebart aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT ceulemanslaurensj aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT vanraemdonckdirk aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT neyrinckarnep aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT godinaslaurent aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT dupontlievenj aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT verledengeertm aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation
AT vosrobin aspergillusspecificiggantibodiesareassociatedwithfungalrelatedcomplicationsandchroniclungallograftdysfunctionafterlungtransplantation