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Hydrogel systems for targeted cancer therapy

When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously...

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Autores principales: Li, Xinlin, Xu, Xinyi, Xu, Mengfei, Geng, Zhaoli, Ji, Ping, Liu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977812/
https://www.ncbi.nlm.nih.gov/pubmed/36873346
http://dx.doi.org/10.3389/fbioe.2023.1140436
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author Li, Xinlin
Xu, Xinyi
Xu, Mengfei
Geng, Zhaoli
Ji, Ping
Liu, Yi
author_facet Li, Xinlin
Xu, Xinyi
Xu, Mengfei
Geng, Zhaoli
Ji, Ping
Liu, Yi
author_sort Li, Xinlin
collection PubMed
description When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer.
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spelling pubmed-99778122023-03-03 Hydrogel systems for targeted cancer therapy Li, Xinlin Xu, Xinyi Xu, Mengfei Geng, Zhaoli Ji, Ping Liu, Yi Front Bioeng Biotechnol Bioengineering and Biotechnology When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9977812/ /pubmed/36873346 http://dx.doi.org/10.3389/fbioe.2023.1140436 Text en Copyright © 2023 Li, Xu, Xu, Geng, Ji and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Li, Xinlin
Xu, Xinyi
Xu, Mengfei
Geng, Zhaoli
Ji, Ping
Liu, Yi
Hydrogel systems for targeted cancer therapy
title Hydrogel systems for targeted cancer therapy
title_full Hydrogel systems for targeted cancer therapy
title_fullStr Hydrogel systems for targeted cancer therapy
title_full_unstemmed Hydrogel systems for targeted cancer therapy
title_short Hydrogel systems for targeted cancer therapy
title_sort hydrogel systems for targeted cancer therapy
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977812/
https://www.ncbi.nlm.nih.gov/pubmed/36873346
http://dx.doi.org/10.3389/fbioe.2023.1140436
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