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Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation

Plasma creatinine is a marker of interest in renal transplantation but data on its kinetics in the first days following transplantation are scarce. The aim of this study was to identify clinically relevant subgroups of creatinine trajectories following renal transplantation and to test their associa...

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Autores principales: Ducousso, Héloïse, Vallée, Maxime, Kerforne, Thomas, Castilla, Ines, Duthe, Fabien, Saulnier, Pierre-Jean, Ragot, Stéphanie, Thierry, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977818/
https://www.ncbi.nlm.nih.gov/pubmed/36873744
http://dx.doi.org/10.3389/ti.2023.10685
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author Ducousso, Héloïse
Vallée, Maxime
Kerforne, Thomas
Castilla, Ines
Duthe, Fabien
Saulnier, Pierre-Jean
Ragot, Stéphanie
Thierry, Antoine
author_facet Ducousso, Héloïse
Vallée, Maxime
Kerforne, Thomas
Castilla, Ines
Duthe, Fabien
Saulnier, Pierre-Jean
Ragot, Stéphanie
Thierry, Antoine
author_sort Ducousso, Héloïse
collection PubMed
description Plasma creatinine is a marker of interest in renal transplantation but data on its kinetics in the first days following transplantation are scarce. The aim of this study was to identify clinically relevant subgroups of creatinine trajectories following renal transplantation and to test their association with graft outcome. Among 496 patients with a first kidney transplant included in the French ASTRE cohort at the Poitiers University hospital, 435 patients from donation after brain death were considered in a latent class modeling. Four distinct classes of creatinine trajectories were identified: “poor recovery” (6% of patients), “intermediate recovery” (47%), “good recovery” (10%) and “optimal recovery” (37%). Cold ischemia time was significantly lower in the “optimal recovery” class. Delayed graft function was more frequent and the number of hemodialysis sessions was higher in the “poor recovery” class. Incidence of graft loss was significantly lower in “optimal recovery” patients with an adjusted risk of graft loss 2.42 and 4.06 times higher in “intermediate recovery” and “poor recovery” patients, respectively. Our study highlights substantial heterogeneity in creatinine trajectories following renal transplantation that may help to identify patients who are more likely to experience a graft loss.
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spelling pubmed-99778182023-03-03 Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation Ducousso, Héloïse Vallée, Maxime Kerforne, Thomas Castilla, Ines Duthe, Fabien Saulnier, Pierre-Jean Ragot, Stéphanie Thierry, Antoine Transpl Int Health Archive Plasma creatinine is a marker of interest in renal transplantation but data on its kinetics in the first days following transplantation are scarce. The aim of this study was to identify clinically relevant subgroups of creatinine trajectories following renal transplantation and to test their association with graft outcome. Among 496 patients with a first kidney transplant included in the French ASTRE cohort at the Poitiers University hospital, 435 patients from donation after brain death were considered in a latent class modeling. Four distinct classes of creatinine trajectories were identified: “poor recovery” (6% of patients), “intermediate recovery” (47%), “good recovery” (10%) and “optimal recovery” (37%). Cold ischemia time was significantly lower in the “optimal recovery” class. Delayed graft function was more frequent and the number of hemodialysis sessions was higher in the “poor recovery” class. Incidence of graft loss was significantly lower in “optimal recovery” patients with an adjusted risk of graft loss 2.42 and 4.06 times higher in “intermediate recovery” and “poor recovery” patients, respectively. Our study highlights substantial heterogeneity in creatinine trajectories following renal transplantation that may help to identify patients who are more likely to experience a graft loss. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9977818/ /pubmed/36873744 http://dx.doi.org/10.3389/ti.2023.10685 Text en Copyright © 2023 Ducousso, Vallée, Kerforne, Castilla, Duthe, Saulnier, Ragot and Thierry. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Ducousso, Héloïse
Vallée, Maxime
Kerforne, Thomas
Castilla, Ines
Duthe, Fabien
Saulnier, Pierre-Jean
Ragot, Stéphanie
Thierry, Antoine
Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation
title Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation
title_full Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation
title_fullStr Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation
title_full_unstemmed Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation
title_short Paving the Way for Personalized Medicine in First Kidney Transplantation: Interest of a Creatininemia Latent Class Analysis in Early Post-transplantation
title_sort paving the way for personalized medicine in first kidney transplantation: interest of a creatininemia latent class analysis in early post-transplantation
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977818/
https://www.ncbi.nlm.nih.gov/pubmed/36873744
http://dx.doi.org/10.3389/ti.2023.10685
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