The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies

Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the ring systems is an imidazoacridinone moiety, with the skeleton identical to the structural base of Symadex. The seco...

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Detalles Bibliográficos
Autores principales: Laskowski, Tomasz, Kosno, Michał, Andrałojć, Witold, Frackowiak, Joanna E., Borzyszkowska-Bukowska, Julia, Szczeblewski, Paweł, Radoń, Nikola, Świerżewska, Maria, Woźny, Anna, Paluszkiewicz, Ewa, Mazerska, Zofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977845/
https://www.ncbi.nlm.nih.gov/pubmed/36859494
http://dx.doi.org/10.1038/s41598-023-30587-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977845/
https://www.ncbi.nlm.nih.gov/pubmed/36859494
http://dx.doi.org/10.1038/s41598-023-30587-y

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