Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

Ischemia reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The role of N(6-)methyladenosine (m6A) modification in AKI remains unclear. Here, we characterize the role of AlkB homolog 5 (ALKBH5) and m6A modification in an I/R-induced renal injury model in male mice. Alkbh5-knock...

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Autores principales: Chen, Juntao, Xu, Cuidi, Yang, Kun, Gao, Rifeng, Cao, Yirui, Liang, Lifei, Chen, Siyue, Xu, Shihao, Rong, Ruiming, Wang, Jina, Zhu, Tongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977869/
https://www.ncbi.nlm.nih.gov/pubmed/36859428
http://dx.doi.org/10.1038/s41467-023-36747-y

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