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Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh

In 2022, one of its worst cholera outbreaks began in Bangladesh and the icddr,b Dhaka hospital treated more than 1300 patients and ca. 42,000 diarrheal cases from March-1 to April-10, 2022(1). Here, we present genomic attributes of V. cholerae O1 responsible for the 2022 Dhaka outbreak and 960 7th p...

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Autores principales: Monir, Md Mamun, Islam, Mohammad Tarequl, Mazumder, Razib, Mondal, Dinesh, Nahar, Kazi Sumaita, Sultana, Marzia, Morita, Masatomo, Ohnishi, Makoto, Huq, Anwar, Watanabe, Haruo, Qadri, Firdausi, Rahman, Mustafizur, Thomson, Nicholas, Seed, Kimberley, Colwell, Rita R., Ahmed, Tahmeed, Alam, Munirul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977884/
https://www.ncbi.nlm.nih.gov/pubmed/36859426
http://dx.doi.org/10.1038/s41467-023-36687-7
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author Monir, Md Mamun
Islam, Mohammad Tarequl
Mazumder, Razib
Mondal, Dinesh
Nahar, Kazi Sumaita
Sultana, Marzia
Morita, Masatomo
Ohnishi, Makoto
Huq, Anwar
Watanabe, Haruo
Qadri, Firdausi
Rahman, Mustafizur
Thomson, Nicholas
Seed, Kimberley
Colwell, Rita R.
Ahmed, Tahmeed
Alam, Munirul
author_facet Monir, Md Mamun
Islam, Mohammad Tarequl
Mazumder, Razib
Mondal, Dinesh
Nahar, Kazi Sumaita
Sultana, Marzia
Morita, Masatomo
Ohnishi, Makoto
Huq, Anwar
Watanabe, Haruo
Qadri, Firdausi
Rahman, Mustafizur
Thomson, Nicholas
Seed, Kimberley
Colwell, Rita R.
Ahmed, Tahmeed
Alam, Munirul
author_sort Monir, Md Mamun
collection PubMed
description In 2022, one of its worst cholera outbreaks began in Bangladesh and the icddr,b Dhaka hospital treated more than 1300 patients and ca. 42,000 diarrheal cases from March-1 to April-10, 2022(1). Here, we present genomic attributes of V. cholerae O1 responsible for the 2022 Dhaka outbreak and 960 7th pandemic El Tor (7PET) strains from 88 countries. Results show strains isolated during the Dhaka outbreak cluster with 7PET wave-3 global clade strains, but comprise subclade BD-1.2, for which the most recent common ancestor appears to be that responsible for recent endemic cholera in India. BD-1.2 strains are present in Bangladesh since 2016, but not establishing dominance over BD-2 lineage strains(2) until 2018 and predominantly associated with endemic cholera. In conclusion, the recent shift in lineage and genetic attributes, including serotype switching of BD-1.2 from Ogawa to Inaba, may explain the increasing number of cholera cases in Bangladesh.
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spelling pubmed-99778842023-03-03 Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh Monir, Md Mamun Islam, Mohammad Tarequl Mazumder, Razib Mondal, Dinesh Nahar, Kazi Sumaita Sultana, Marzia Morita, Masatomo Ohnishi, Makoto Huq, Anwar Watanabe, Haruo Qadri, Firdausi Rahman, Mustafizur Thomson, Nicholas Seed, Kimberley Colwell, Rita R. Ahmed, Tahmeed Alam, Munirul Nat Commun Article In 2022, one of its worst cholera outbreaks began in Bangladesh and the icddr,b Dhaka hospital treated more than 1300 patients and ca. 42,000 diarrheal cases from March-1 to April-10, 2022(1). Here, we present genomic attributes of V. cholerae O1 responsible for the 2022 Dhaka outbreak and 960 7th pandemic El Tor (7PET) strains from 88 countries. Results show strains isolated during the Dhaka outbreak cluster with 7PET wave-3 global clade strains, but comprise subclade BD-1.2, for which the most recent common ancestor appears to be that responsible for recent endemic cholera in India. BD-1.2 strains are present in Bangladesh since 2016, but not establishing dominance over BD-2 lineage strains(2) until 2018 and predominantly associated with endemic cholera. In conclusion, the recent shift in lineage and genetic attributes, including serotype switching of BD-1.2 from Ogawa to Inaba, may explain the increasing number of cholera cases in Bangladesh. Nature Publishing Group UK 2023-03-01 /pmc/articles/PMC9977884/ /pubmed/36859426 http://dx.doi.org/10.1038/s41467-023-36687-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Monir, Md Mamun
Islam, Mohammad Tarequl
Mazumder, Razib
Mondal, Dinesh
Nahar, Kazi Sumaita
Sultana, Marzia
Morita, Masatomo
Ohnishi, Makoto
Huq, Anwar
Watanabe, Haruo
Qadri, Firdausi
Rahman, Mustafizur
Thomson, Nicholas
Seed, Kimberley
Colwell, Rita R.
Ahmed, Tahmeed
Alam, Munirul
Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh
title Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh
title_full Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh
title_fullStr Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh
title_full_unstemmed Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh
title_short Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh
title_sort genomic attributes of vibrio cholerae o1 responsible for 2022 massive cholera outbreak in bangladesh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977884/
https://www.ncbi.nlm.nih.gov/pubmed/36859426
http://dx.doi.org/10.1038/s41467-023-36687-7
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