Myocardial Metabolism in Heart Failure

PURPOSE OF REVIEW: Myocardial metabolism is intricately linked to cardiac function. Perturbations of cardiac energy metabolism result in an energy-starved heart and the development of contractile dysfunction. In this review, we discuss alterations in myocardial energy supply, transcriptional changes...

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Detalles Bibliográficos
Autores principales: Ng, Sher May, Neubauer, Stefan, Rider, Oliver J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977885/
https://www.ncbi.nlm.nih.gov/pubmed/36800045
http://dx.doi.org/10.1007/s11897-023-00589-y
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author Ng, Sher May
Neubauer, Stefan
Rider, Oliver J
author_facet Ng, Sher May
Neubauer, Stefan
Rider, Oliver J
author_sort Ng, Sher May
collection PubMed
description PURPOSE OF REVIEW: Myocardial metabolism is intricately linked to cardiac function. Perturbations of cardiac energy metabolism result in an energy-starved heart and the development of contractile dysfunction. In this review, we discuss alterations in myocardial energy supply, transcriptional changes in response to different energy demands, and mitochondrial function in the development of heart failure. RECENT FINDINGS: Recent studies on substrate modulation through modifying energy substrate supply have shown cardioprotective properties. In addition, large cardiovascular outcome trials of anti-diabetic agents have demonstrated prognostic benefit, suggesting the importance of myocardial metabolism in cardiac function. SUMMARY: Understanding molecular and transcriptional controls of cardiac metabolism promises new research avenues for metabolic treatment targets. Future studies assessing the impact of substrate modulation on cardiac energetic status and function will better inform development of metabolic therapies.
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spelling pubmed-99778852023-03-03 Myocardial Metabolism in Heart Failure Ng, Sher May Neubauer, Stefan Rider, Oliver J Curr Heart Fail Rep Article PURPOSE OF REVIEW: Myocardial metabolism is intricately linked to cardiac function. Perturbations of cardiac energy metabolism result in an energy-starved heart and the development of contractile dysfunction. In this review, we discuss alterations in myocardial energy supply, transcriptional changes in response to different energy demands, and mitochondrial function in the development of heart failure. RECENT FINDINGS: Recent studies on substrate modulation through modifying energy substrate supply have shown cardioprotective properties. In addition, large cardiovascular outcome trials of anti-diabetic agents have demonstrated prognostic benefit, suggesting the importance of myocardial metabolism in cardiac function. SUMMARY: Understanding molecular and transcriptional controls of cardiac metabolism promises new research avenues for metabolic treatment targets. Future studies assessing the impact of substrate modulation on cardiac energetic status and function will better inform development of metabolic therapies. Springer US 2023-02-17 2023 /pmc/articles/PMC9977885/ /pubmed/36800045 http://dx.doi.org/10.1007/s11897-023-00589-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ng, Sher May
Neubauer, Stefan
Rider, Oliver J
Myocardial Metabolism in Heart Failure
title Myocardial Metabolism in Heart Failure
title_full Myocardial Metabolism in Heart Failure
title_fullStr Myocardial Metabolism in Heart Failure
title_full_unstemmed Myocardial Metabolism in Heart Failure
title_short Myocardial Metabolism in Heart Failure
title_sort myocardial metabolism in heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977885/
https://www.ncbi.nlm.nih.gov/pubmed/36800045
http://dx.doi.org/10.1007/s11897-023-00589-y
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