Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction

Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) is now twenty-five years old, it still represents a milestone in PD research. Abnormal forms of α-syn trigger selective and progressive neuronal death through mitochondrial impairment,...

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Detalles Bibliográficos
Autores principales: Calabresi, Paolo, Mechelli, Alessandro, Natale, Giuseppina, Volpicelli-Daley, Laura, Di Lazzaro, Giulia, Ghiglieri, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977911/
https://www.ncbi.nlm.nih.gov/pubmed/36859484
http://dx.doi.org/10.1038/s41419-023-05672-9

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