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Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells

Understanding the molecular basis of arrestin-mediated regulation of GPCRs is critical for deciphering signaling mechanisms and designing functional selectivity. However, structural studies of GPCR-arrestin complexes are hampered by their highly dynamic nature. Here, we dissect the interaction of ar...

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Detalles Bibliográficos
Autores principales:	Aydin, Yasmin, Böttke, Thore, Lam, Jordy Homing, Ernicke, Stefan, Fortmann, Anna, Tretbar, Maik, Zarzycka, Barbara, Gurevich, Vsevolod V., Katritch, Vsevolod, Coin, Irene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977954/ https://www.ncbi.nlm.nih.gov/pubmed/36859440 http://dx.doi.org/10.1038/s41467-023-36797-2

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