A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons

INTRODUCTION: Human-derived induced pluripotent stem cell (iPSC) models of brain promise to advance our understanding of neurotoxic consequences of drug use. However, how well these models recapitulate the actual genomic landscape and cell function, as well as the drug-induced alterations, remains t...

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Detalles Bibliográficos
Autores principales: Mendez, Emily F., Grimm, Sandra L., Stertz, Laura, Gorski, Damian, Movva, Sai V., Najera, Katherine, Moriel, Karla, Meyer, Thomas D., Fries, Gabriel R., Coarfa, Cristian, Walss-Bass, Consuelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978009/
https://www.ncbi.nlm.nih.gov/pubmed/36873219
http://dx.doi.org/10.3389/fpsyt.2023.1070556

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