Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation

Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. The central event leading to the pathology in the diseases is the conversion of PrP(C) into PrP(Sc) and its accumulation in the central nervous system. Previous studies demonstrated that recombinant PrP (rPrP)...

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Detalles Bibliográficos
Autores principales: Kopycka, Katarzyna, Maddison, Ben C., Gough, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978027/
https://www.ncbi.nlm.nih.gov/pubmed/36859422
http://dx.doi.org/10.1038/s41598-023-30202-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978027/
https://www.ncbi.nlm.nih.gov/pubmed/36859422
http://dx.doi.org/10.1038/s41598-023-30202-0

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