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Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation
Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. The central event leading to the pathology in the diseases is the conversion of PrP(C) into PrP(Sc) and its accumulation in the central nervous system. Previous studies demonstrated that recombinant PrP (rPrP)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978027/ https://www.ncbi.nlm.nih.gov/pubmed/36859422 http://dx.doi.org/10.1038/s41598-023-30202-0 |