Human uridine 5′-monophosphate synthase stores metabolic potential in inactive biomolecular condensates

Human uridine 5′-monophosphate synthase (HsUMPS) is a bifunctional enzyme that catalyzes the final two steps in de novo pyrimidine biosynthesis. The individual orotate phosphoribosyl transferase and orotidine monophosphate domains have been well characterized, but little is known about the overall s...

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Detalles Bibliográficos
Autores principales: Kim-Holzapfel, Deborah M., Dey, Raja, Richardson, Brian C., Arachchige, Danushka, Reddy, Kanamata, De Vitto, Humberto, Bhandari, Janarjan, French, Jarrod B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978035/
https://www.ncbi.nlm.nih.gov/pubmed/36708921
http://dx.doi.org/10.1016/j.jbc.2023.102949

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