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Organocatalytic asymmetric synthesis of P-stereogenic molecules

P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodol...

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Autores principales: Liu, Junyang, Chen, Hang, Wang, Min, He, Wangjin, Yan, Jia-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978094/
https://www.ncbi.nlm.nih.gov/pubmed/36874062
http://dx.doi.org/10.3389/fchem.2023.1132025
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author Liu, Junyang
Chen, Hang
Wang, Min
He, Wangjin
Yan, Jia-Lei
author_facet Liu, Junyang
Chen, Hang
Wang, Min
He, Wangjin
Yan, Jia-Lei
author_sort Liu, Junyang
collection PubMed
description P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds.
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spelling pubmed-99780942023-03-03 Organocatalytic asymmetric synthesis of P-stereogenic molecules Liu, Junyang Chen, Hang Wang, Min He, Wangjin Yan, Jia-Lei Front Chem Chemistry P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978094/ /pubmed/36874062 http://dx.doi.org/10.3389/fchem.2023.1132025 Text en Copyright © 2023 Liu, Chen, Wang, He and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Liu, Junyang
Chen, Hang
Wang, Min
He, Wangjin
Yan, Jia-Lei
Organocatalytic asymmetric synthesis of P-stereogenic molecules
title Organocatalytic asymmetric synthesis of P-stereogenic molecules
title_full Organocatalytic asymmetric synthesis of P-stereogenic molecules
title_fullStr Organocatalytic asymmetric synthesis of P-stereogenic molecules
title_full_unstemmed Organocatalytic asymmetric synthesis of P-stereogenic molecules
title_short Organocatalytic asymmetric synthesis of P-stereogenic molecules
title_sort organocatalytic asymmetric synthesis of p-stereogenic molecules
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978094/
https://www.ncbi.nlm.nih.gov/pubmed/36874062
http://dx.doi.org/10.3389/fchem.2023.1132025
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