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Organocatalytic asymmetric synthesis of P-stereogenic molecules
P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodol...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978094/ https://www.ncbi.nlm.nih.gov/pubmed/36874062 http://dx.doi.org/10.3389/fchem.2023.1132025 |
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author | Liu, Junyang Chen, Hang Wang, Min He, Wangjin Yan, Jia-Lei |
author_facet | Liu, Junyang Chen, Hang Wang, Min He, Wangjin Yan, Jia-Lei |
author_sort | Liu, Junyang |
collection | PubMed |
description | P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds. |
format | Online Article Text |
id | pubmed-9978094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99780942023-03-03 Organocatalytic asymmetric synthesis of P-stereogenic molecules Liu, Junyang Chen, Hang Wang, Min He, Wangjin Yan, Jia-Lei Front Chem Chemistry P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978094/ /pubmed/36874062 http://dx.doi.org/10.3389/fchem.2023.1132025 Text en Copyright © 2023 Liu, Chen, Wang, He and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Liu, Junyang Chen, Hang Wang, Min He, Wangjin Yan, Jia-Lei Organocatalytic asymmetric synthesis of P-stereogenic molecules |
title | Organocatalytic asymmetric synthesis of P-stereogenic molecules |
title_full | Organocatalytic asymmetric synthesis of P-stereogenic molecules |
title_fullStr | Organocatalytic asymmetric synthesis of P-stereogenic molecules |
title_full_unstemmed | Organocatalytic asymmetric synthesis of P-stereogenic molecules |
title_short | Organocatalytic asymmetric synthesis of P-stereogenic molecules |
title_sort | organocatalytic asymmetric synthesis of p-stereogenic molecules |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978094/ https://www.ncbi.nlm.nih.gov/pubmed/36874062 http://dx.doi.org/10.3389/fchem.2023.1132025 |
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