The role of ROS-induced pyroptosis in CVD

Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD. However, the signaling pathway ROS-in...

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Autores principales: Tian, Kaijiang, Yang, Yu, Zhou, Kun, Deng, Nianhua, Tian, Zhen, Wu, Zefan, Liu, Xiyan, Zhang, Fan, Jiang, Zhisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978107/
https://www.ncbi.nlm.nih.gov/pubmed/36873396
http://dx.doi.org/10.3389/fcvm.2023.1116509
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author Tian, Kaijiang
Yang, Yu
Zhou, Kun
Deng, Nianhua
Tian, Zhen
Wu, Zefan
Liu, Xiyan
Zhang, Fan
Jiang, Zhisheng
author_facet Tian, Kaijiang
Yang, Yu
Zhou, Kun
Deng, Nianhua
Tian, Zhen
Wu, Zefan
Liu, Xiyan
Zhang, Fan
Jiang, Zhisheng
author_sort Tian, Kaijiang
collection PubMed
description Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD. However, the signaling pathway ROS-induced pyroptosis has yet to be fully understood. This article reviews the specific mechanism of ROS-mediated pyroptosis in vascular endothelial cells, macrophages, and cardiomyocytes. Current evidence shows that ROS-mediated pyroptosis is a new target for the prevention and treatment of cardiovascular diseases such as atherosclerosis (AS), myocardial ischemia-reperfusion injury (MIRI), and heart failure (HF).
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spelling pubmed-99781072023-03-03 The role of ROS-induced pyroptosis in CVD Tian, Kaijiang Yang, Yu Zhou, Kun Deng, Nianhua Tian, Zhen Wu, Zefan Liu, Xiyan Zhang, Fan Jiang, Zhisheng Front Cardiovasc Med Cardiovascular Medicine Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD. However, the signaling pathway ROS-induced pyroptosis has yet to be fully understood. This article reviews the specific mechanism of ROS-mediated pyroptosis in vascular endothelial cells, macrophages, and cardiomyocytes. Current evidence shows that ROS-mediated pyroptosis is a new target for the prevention and treatment of cardiovascular diseases such as atherosclerosis (AS), myocardial ischemia-reperfusion injury (MIRI), and heart failure (HF). Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978107/ /pubmed/36873396 http://dx.doi.org/10.3389/fcvm.2023.1116509 Text en Copyright © 2023 Tian, Yang, Zhou, Deng, Tian, Wu, Liu, Zhang and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Tian, Kaijiang
Yang, Yu
Zhou, Kun
Deng, Nianhua
Tian, Zhen
Wu, Zefan
Liu, Xiyan
Zhang, Fan
Jiang, Zhisheng
The role of ROS-induced pyroptosis in CVD
title The role of ROS-induced pyroptosis in CVD
title_full The role of ROS-induced pyroptosis in CVD
title_fullStr The role of ROS-induced pyroptosis in CVD
title_full_unstemmed The role of ROS-induced pyroptosis in CVD
title_short The role of ROS-induced pyroptosis in CVD
title_sort role of ros-induced pyroptosis in cvd
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978107/
https://www.ncbi.nlm.nih.gov/pubmed/36873396
http://dx.doi.org/10.3389/fcvm.2023.1116509
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