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A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation
Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models of PND are usually induced in mice over 18 months of age, which imposes expensive economic and time costs for PND-related studies. Sleep...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978123/ https://www.ncbi.nlm.nih.gov/pubmed/36130912 http://dx.doi.org/10.1538/expanim.22-0053 |
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author | Wu, Tingmei Li, Min Tian, Li Cong, Peilin Huang, Xinwei Wu, Huanghui Zhang, Qian Zhang, Hong Xiong, Lize |
author_facet | Wu, Tingmei Li, Min Tian, Li Cong, Peilin Huang, Xinwei Wu, Huanghui Zhang, Qian Zhang, Hong Xiong, Lize |
author_sort | Wu, Tingmei |
collection | PubMed |
description | Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models of PND are usually induced in mice over 18 months of age, which imposes expensive economic and time costs for PND-related studies. Sleep disorders, including sleep fragmentation, are reported to aggravate memory impairment in neurocognitive-related diseases such as Alzheimer’s disease (AD). Therefore, the aim of the present study was to explore whether a PND model could be constructed in younger mice with the help of fragmented sleep. We found that fragmented sleep followed by laparotomy under isoflurane anesthesia could stably induce PND in 15-month-old mice. To determine whether the neurocognitive decline in this model could be salvaged by clinical treatments, we administered repetitive transcranial magnetic stimulation (rTMS) to the model mice before anesthesia and surgery. We found that 10 days of high-frequency rTMS (HF-rTMS) could improve spatial learning and memory deficits in this modified PND model. We are the first to successfully construct a PND model in younger mice,which is more economical, that can be used as an alternative model for future PND studies. |
format | Online Article Text |
id | pubmed-9978123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99781232023-03-03 A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation Wu, Tingmei Li, Min Tian, Li Cong, Peilin Huang, Xinwei Wu, Huanghui Zhang, Qian Zhang, Hong Xiong, Lize Exp Anim Original Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models of PND are usually induced in mice over 18 months of age, which imposes expensive economic and time costs for PND-related studies. Sleep disorders, including sleep fragmentation, are reported to aggravate memory impairment in neurocognitive-related diseases such as Alzheimer’s disease (AD). Therefore, the aim of the present study was to explore whether a PND model could be constructed in younger mice with the help of fragmented sleep. We found that fragmented sleep followed by laparotomy under isoflurane anesthesia could stably induce PND in 15-month-old mice. To determine whether the neurocognitive decline in this model could be salvaged by clinical treatments, we administered repetitive transcranial magnetic stimulation (rTMS) to the model mice before anesthesia and surgery. We found that 10 days of high-frequency rTMS (HF-rTMS) could improve spatial learning and memory deficits in this modified PND model. We are the first to successfully construct a PND model in younger mice,which is more economical, that can be used as an alternative model for future PND studies. Japanese Association for Laboratory Animal Science 2022-09-22 2023 /pmc/articles/PMC9978123/ /pubmed/36130912 http://dx.doi.org/10.1538/expanim.22-0053 Text en ©2023 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Wu, Tingmei Li, Min Tian, Li Cong, Peilin Huang, Xinwei Wu, Huanghui Zhang, Qian Zhang, Hong Xiong, Lize A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation |
title | A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation |
title_full | A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation |
title_fullStr | A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation |
title_full_unstemmed | A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation |
title_short | A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation |
title_sort | modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978123/ https://www.ncbi.nlm.nih.gov/pubmed/36130912 http://dx.doi.org/10.1538/expanim.22-0053 |
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