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An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application
Osteoarthritis (OA) is the most common progressive condition affecting joints. It mainly affects the knees and hips as predominant weight-bearing joints. Knee osteoarthritis (KOA) accounts for a large proportion of osteoarthritis and presents numerous symptoms that impair quality of life, such as st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978162/ https://www.ncbi.nlm.nih.gov/pubmed/36873347 http://dx.doi.org/10.3389/fbioe.2023.1128856 |
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author | Amirsaadat, Soumayeh Amirazad, Halimeh Hashemihesar, Ramin Zarghami, Nosratollah |
author_facet | Amirsaadat, Soumayeh Amirazad, Halimeh Hashemihesar, Ramin Zarghami, Nosratollah |
author_sort | Amirsaadat, Soumayeh |
collection | PubMed |
description | Osteoarthritis (OA) is the most common progressive condition affecting joints. It mainly affects the knees and hips as predominant weight-bearing joints. Knee osteoarthritis (KOA) accounts for a large proportion of osteoarthritis and presents numerous symptoms that impair quality of life, such as stiffness, pain, dysfunction, and even deformity. For more than two decades, intra-articular (IA) treatment options for managing knee osteoarthritis have included analgesics, hyaluronic acid (HA), corticosteroids, and some unproven alternative therapies. Before effective disease-modifying treatments for knee osteoarthritis, treatments are primarily symptomatic, mainly including intra-articular corticosteroids and hyaluronic acid, so these agents represent the most frequently used class of drugs for managing knee osteoarthritis. But research suggests other factors, such as the placebo effect, have an essential role in the effectiveness of these drugs. Several novel intra-articular therapies are currently in the clinical trial processes, such as biological therapies, gene and cell therapies. Besides, it has been shown that the development of novel drug nanocarriers and delivery systems could improve the effectiveness of therapeutic agents in osteoarthritis. This review discusses the various treatment methods and delivery systems for knee osteoarthritis and the new agents that have been introduced or are in development. |
format | Online Article Text |
id | pubmed-9978162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99781622023-03-03 An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application Amirsaadat, Soumayeh Amirazad, Halimeh Hashemihesar, Ramin Zarghami, Nosratollah Front Bioeng Biotechnol Bioengineering and Biotechnology Osteoarthritis (OA) is the most common progressive condition affecting joints. It mainly affects the knees and hips as predominant weight-bearing joints. Knee osteoarthritis (KOA) accounts for a large proportion of osteoarthritis and presents numerous symptoms that impair quality of life, such as stiffness, pain, dysfunction, and even deformity. For more than two decades, intra-articular (IA) treatment options for managing knee osteoarthritis have included analgesics, hyaluronic acid (HA), corticosteroids, and some unproven alternative therapies. Before effective disease-modifying treatments for knee osteoarthritis, treatments are primarily symptomatic, mainly including intra-articular corticosteroids and hyaluronic acid, so these agents represent the most frequently used class of drugs for managing knee osteoarthritis. But research suggests other factors, such as the placebo effect, have an essential role in the effectiveness of these drugs. Several novel intra-articular therapies are currently in the clinical trial processes, such as biological therapies, gene and cell therapies. Besides, it has been shown that the development of novel drug nanocarriers and delivery systems could improve the effectiveness of therapeutic agents in osteoarthritis. This review discusses the various treatment methods and delivery systems for knee osteoarthritis and the new agents that have been introduced or are in development. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978162/ /pubmed/36873347 http://dx.doi.org/10.3389/fbioe.2023.1128856 Text en Copyright © 2023 Amirsaadat, Amirazad, Hashemihesar and Zarghami. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Amirsaadat, Soumayeh Amirazad, Halimeh Hashemihesar, Ramin Zarghami, Nosratollah An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application |
title | An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application |
title_full | An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application |
title_fullStr | An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application |
title_full_unstemmed | An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application |
title_short | An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application |
title_sort | update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: possible clinical application |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978162/ https://www.ncbi.nlm.nih.gov/pubmed/36873347 http://dx.doi.org/10.3389/fbioe.2023.1128856 |
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