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Statistical multi-level shape models for scalable modeling of multi-organ anatomies

Statistical shape modeling is an indispensable tool in the quantitative analysis of anatomies. Particle-based shape modeling (PSM) is a state-of-the-art approach that enables the learning of population-level shape representation from medical imaging data (e.g., CT, MRI) and the associated 3D models...

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Autores principales: Khan, Nawazish, Peterson, Andrew C., Aubert, Benjamin, Morris, Alan, Atkins, Penny R., Lenz, Amy L., Anderson, Andrew E., Elhabian, Shireen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978224/
https://www.ncbi.nlm.nih.gov/pubmed/36873362
http://dx.doi.org/10.3389/fbioe.2023.1089113
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author Khan, Nawazish
Peterson, Andrew C.
Aubert, Benjamin
Morris, Alan
Atkins, Penny R.
Lenz, Amy L.
Anderson, Andrew E.
Elhabian, Shireen Y.
author_facet Khan, Nawazish
Peterson, Andrew C.
Aubert, Benjamin
Morris, Alan
Atkins, Penny R.
Lenz, Amy L.
Anderson, Andrew E.
Elhabian, Shireen Y.
author_sort Khan, Nawazish
collection PubMed
description Statistical shape modeling is an indispensable tool in the quantitative analysis of anatomies. Particle-based shape modeling (PSM) is a state-of-the-art approach that enables the learning of population-level shape representation from medical imaging data (e.g., CT, MRI) and the associated 3D models of anatomy generated from them. PSM optimizes the placement of a dense set of landmarks (i.e., correspondence points) on a given shape cohort. PSM supports multi-organ modeling as a particular case of the conventional single-organ framework via a global statistical model, where multi-structure anatomy is considered as a single structure. However, global multi-organ models are not scalable for many organs, induce anatomical inconsistencies, and result in entangled shape statistics where modes of shape variation reflect both within- and between-organ variations. Hence, there is a need for an efficient modeling approach that can capture the inter-organ relations (i.e., pose variations) of the complex anatomy while simultaneously optimizing the morphological changes of each organ and capturing the population-level statistics. This paper leverages the PSM approach and proposes a new approach for correspondence-point optimization of multiple organs that overcomes these limitations. The central idea of multilevel component analysis, is that the shape statistics consists of two mutually orthogonal subspaces: the within-organ subspace and the between-organ subspace. We formulate the correspondence optimization objective using this generative model. We evaluate the proposed method using synthetic shape data and clinical data for articulated joint structures of the spine, foot and ankle, and hip joint.
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spelling pubmed-99782242023-03-03 Statistical multi-level shape models for scalable modeling of multi-organ anatomies Khan, Nawazish Peterson, Andrew C. Aubert, Benjamin Morris, Alan Atkins, Penny R. Lenz, Amy L. Anderson, Andrew E. Elhabian, Shireen Y. Front Bioeng Biotechnol Bioengineering and Biotechnology Statistical shape modeling is an indispensable tool in the quantitative analysis of anatomies. Particle-based shape modeling (PSM) is a state-of-the-art approach that enables the learning of population-level shape representation from medical imaging data (e.g., CT, MRI) and the associated 3D models of anatomy generated from them. PSM optimizes the placement of a dense set of landmarks (i.e., correspondence points) on a given shape cohort. PSM supports multi-organ modeling as a particular case of the conventional single-organ framework via a global statistical model, where multi-structure anatomy is considered as a single structure. However, global multi-organ models are not scalable for many organs, induce anatomical inconsistencies, and result in entangled shape statistics where modes of shape variation reflect both within- and between-organ variations. Hence, there is a need for an efficient modeling approach that can capture the inter-organ relations (i.e., pose variations) of the complex anatomy while simultaneously optimizing the morphological changes of each organ and capturing the population-level statistics. This paper leverages the PSM approach and proposes a new approach for correspondence-point optimization of multiple organs that overcomes these limitations. The central idea of multilevel component analysis, is that the shape statistics consists of two mutually orthogonal subspaces: the within-organ subspace and the between-organ subspace. We formulate the correspondence optimization objective using this generative model. We evaluate the proposed method using synthetic shape data and clinical data for articulated joint structures of the spine, foot and ankle, and hip joint. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978224/ /pubmed/36873362 http://dx.doi.org/10.3389/fbioe.2023.1089113 Text en Copyright © 2023 Khan, Peterson, Aubert, Morris, Atkins, Lenz, Anderson and Elhabian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Khan, Nawazish
Peterson, Andrew C.
Aubert, Benjamin
Morris, Alan
Atkins, Penny R.
Lenz, Amy L.
Anderson, Andrew E.
Elhabian, Shireen Y.
Statistical multi-level shape models for scalable modeling of multi-organ anatomies
title Statistical multi-level shape models for scalable modeling of multi-organ anatomies
title_full Statistical multi-level shape models for scalable modeling of multi-organ anatomies
title_fullStr Statistical multi-level shape models for scalable modeling of multi-organ anatomies
title_full_unstemmed Statistical multi-level shape models for scalable modeling of multi-organ anatomies
title_short Statistical multi-level shape models for scalable modeling of multi-organ anatomies
title_sort statistical multi-level shape models for scalable modeling of multi-organ anatomies
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978224/
https://www.ncbi.nlm.nih.gov/pubmed/36873362
http://dx.doi.org/10.3389/fbioe.2023.1089113
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