Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection

Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in wh...

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Detalles Bibliográficos
Autores principales: Li, Yunqi, Lefebvre, Francois, Nakku-Joloba, Edith, Ronald, Allan, Gray, Glenda, de Bruyn, Guy, Kiarie, James, Celum, Connie, Cameron, Mark J, Lingappa, Jairam R, Mackelprang, Romel D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978315/
https://www.ncbi.nlm.nih.gov/pubmed/36637125
http://dx.doi.org/10.1093/infdis/jiac498
Descripción
Sumario:Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in which couples’ HIV-1 exposures were quantified based on unprotected sex frequency and viral load of the partner with HIV-1. We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus may be a signature for increased acquisition risk.

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