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Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma

Esophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant histological subtype of EC that has unique etiology, molecular profiles, and clinicopathological features. Although systemic chemother...

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Detalles Bibliográficos
Autores principales: Ooki, Akira, Osumi, Hiroki, Chin, Keisho, Watanabe, Masayuki, Yamaguchi, Kensei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978325/
https://www.ncbi.nlm.nih.gov/pubmed/36872946
http://dx.doi.org/10.1177/17588359221138377
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author Ooki, Akira
Osumi, Hiroki
Chin, Keisho
Watanabe, Masayuki
Yamaguchi, Kensei
author_facet Ooki, Akira
Osumi, Hiroki
Chin, Keisho
Watanabe, Masayuki
Yamaguchi, Kensei
author_sort Ooki, Akira
collection PubMed
description Esophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant histological subtype of EC that has unique etiology, molecular profiles, and clinicopathological features. Although systemic chemotherapy, including cytotoxic agents and immune checkpoint inhibitors, is the main therapeutic option for recurrent or metastatic ESCC patients, the clinical benefits are limited with poor prognosis. Personalized molecular-targeted therapies have been hampered due to the lack of robust treatment efficacy in clinical trials. Therefore, there is an urgent need to develop effective therapeutic strategies. In this review, we summarize the molecular profiles of ESCC based on the findings of pivotal comprehensive molecular analyses, highlighting potent therapeutic targets for establishing future precision medicine for ESCC patients, with the most recent results of clinical trials.
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spelling pubmed-99783252023-03-03 Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma Ooki, Akira Osumi, Hiroki Chin, Keisho Watanabe, Masayuki Yamaguchi, Kensei Ther Adv Med Oncol Review Esophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant histological subtype of EC that has unique etiology, molecular profiles, and clinicopathological features. Although systemic chemotherapy, including cytotoxic agents and immune checkpoint inhibitors, is the main therapeutic option for recurrent or metastatic ESCC patients, the clinical benefits are limited with poor prognosis. Personalized molecular-targeted therapies have been hampered due to the lack of robust treatment efficacy in clinical trials. Therefore, there is an urgent need to develop effective therapeutic strategies. In this review, we summarize the molecular profiles of ESCC based on the findings of pivotal comprehensive molecular analyses, highlighting potent therapeutic targets for establishing future precision medicine for ESCC patients, with the most recent results of clinical trials. SAGE Publications 2023-01-12 /pmc/articles/PMC9978325/ /pubmed/36872946 http://dx.doi.org/10.1177/17588359221138377 Text en © The Author(s), 2023. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Ooki, Akira
Osumi, Hiroki
Chin, Keisho
Watanabe, Masayuki
Yamaguchi, Kensei
Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
title Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
title_full Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
title_fullStr Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
title_full_unstemmed Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
title_short Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
title_sort potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978325/
https://www.ncbi.nlm.nih.gov/pubmed/36872946
http://dx.doi.org/10.1177/17588359221138377
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