Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice

INTRODUCTION: Lipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome-modulating interventions against lupus. LPS can be expressed as one of two chemotypes: smooth LPS (S-LPS) or rough LPS (R-LPS)...

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Detalles Bibliográficos
Autores principales: Favor, Olivia K., Chauhan, Preeti S., Pourmand, Elham, Edwards, Angel M., Wagner, James G., Lewandowski, Ryan P., Heine, Lauren K., Harkema, Jack R., Lee, Kin Sing Stephen, Pestka, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978350/
https://www.ncbi.nlm.nih.gov/pubmed/36875087
http://dx.doi.org/10.3389/fimmu.2023.1124910

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