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Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system
Particulate matter is an air pollutant composed of various components, and has adverse effects on the human body. Particulate matter is known to induce cell death by generating an imbalance in the antioxidant system; however, the underlying mechanism has not been elucidated. In the present study, we...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978363/ https://www.ncbi.nlm.nih.gov/pubmed/36476270 http://dx.doi.org/10.5483/BMBRep.2022-0139 |
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author | Park, Minkyung Cho, Young-Lai Choi, Yumin Min, Jeong-Ki Park, Young-Jun Yoon, Sung-Jin Kim, Dae-Soo Son, Mi-Young Chung, Su Wol Lee, Heedoo Lee, Seon-Jin |
author_facet | Park, Minkyung Cho, Young-Lai Choi, Yumin Min, Jeong-Ki Park, Young-Jun Yoon, Sung-Jin Kim, Dae-Soo Son, Mi-Young Chung, Su Wol Lee, Heedoo Lee, Seon-Jin |
author_sort | Park, Minkyung |
collection | PubMed |
description | Particulate matter is an air pollutant composed of various components, and has adverse effects on the human body. Particulate matter is known to induce cell death by generating an imbalance in the antioxidant system; however, the underlying mechanism has not been elucidated. In the present study, we demonstrated the cytotoxic effects of the size and composition of particulate matter on small intestine cells. We found that particulate matter 2.5 (PM(2.5)) with extraction ion (EI) components (PM(2.5) EI), is more cytotoxic than PM containing only polycyclic aromatic hydrocarbons (PAHs). Additionally, PM-induced cell death is characteristic of ferroptosis, and includes iron accumulation, lipid peroxidation, and reactive oxygen species (ROS) generation. Furthermore, ferroptosis inhibitor as liproxstatin-1 and iron-chelator as deferiprone attenuated cell mortality, lipid peroxidation, iron accumulation, and ROS production after PM(2.5) EI treatment in human small intestinal cells. These results suggest that PM(2.5) EI may increase ferroptotic-cell death by iron accumulation and ROS generation, and offer a potential therapeutic clue for inflammatory bowel diseases in human small intestinal cells. |
format | Online Article Text |
id | pubmed-9978363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-99783632023-03-03 Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system Park, Minkyung Cho, Young-Lai Choi, Yumin Min, Jeong-Ki Park, Young-Jun Yoon, Sung-Jin Kim, Dae-Soo Son, Mi-Young Chung, Su Wol Lee, Heedoo Lee, Seon-Jin BMB Rep Article Particulate matter is an air pollutant composed of various components, and has adverse effects on the human body. Particulate matter is known to induce cell death by generating an imbalance in the antioxidant system; however, the underlying mechanism has not been elucidated. In the present study, we demonstrated the cytotoxic effects of the size and composition of particulate matter on small intestine cells. We found that particulate matter 2.5 (PM(2.5)) with extraction ion (EI) components (PM(2.5) EI), is more cytotoxic than PM containing only polycyclic aromatic hydrocarbons (PAHs). Additionally, PM-induced cell death is characteristic of ferroptosis, and includes iron accumulation, lipid peroxidation, and reactive oxygen species (ROS) generation. Furthermore, ferroptosis inhibitor as liproxstatin-1 and iron-chelator as deferiprone attenuated cell mortality, lipid peroxidation, iron accumulation, and ROS production after PM(2.5) EI treatment in human small intestinal cells. These results suggest that PM(2.5) EI may increase ferroptotic-cell death by iron accumulation and ROS generation, and offer a potential therapeutic clue for inflammatory bowel diseases in human small intestinal cells. Korean Society for Biochemistry and Molecular Biology 2023-02-28 2023-01-31 /pmc/articles/PMC9978363/ /pubmed/36476270 http://dx.doi.org/10.5483/BMBRep.2022-0139 Text en Copyright © 2023 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Park, Minkyung Cho, Young-Lai Choi, Yumin Min, Jeong-Ki Park, Young-Jun Yoon, Sung-Jin Kim, Dae-Soo Son, Mi-Young Chung, Su Wol Lee, Heedoo Lee, Seon-Jin Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system |
title | Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system |
title_full | Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system |
title_fullStr | Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system |
title_full_unstemmed | Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system |
title_short | Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system |
title_sort | particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978363/ https://www.ncbi.nlm.nih.gov/pubmed/36476270 http://dx.doi.org/10.5483/BMBRep.2022-0139 |
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