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Hypoxia-inducible factor 1α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cells

Chronic myeloid leukemia (CML) has a markedly improved prognosis with the use of breakpoint cluster region-abelson 1 (BCR-ABL1) tyrosine kinase inhibitors (BCR-ABL1 TKIs). However, approximately 40% of patients are resistant or intolerant to BCR-ABL1 TKIs. Hypoxia-inducible factor 1α (HIF-1α) is a h...

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Detalles Bibliográficos
Autores principales:	Tsubaki, Masanobu, Takeda, Tomoya, Matsuda, Takuya, Kimura, Akihiro, Tanaka, Remi, Nagayoshi, Sakiko, Hoshida, Tadafumi, Tanabe, Kazufumi, Nishida, Shozo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978365/ https://www.ncbi.nlm.nih.gov/pubmed/36195570 http://dx.doi.org/10.5483/BMBRep.2022-0095

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