Protein homeostasis in aging and cancer

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can impr...

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Autores principales: Chen, Xiao-Qiong, Shen, Tao, Fang, Shao-Jun, Sun, Xiao-Min, Li, Guo-Yu, Li, Yun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978402/
https://www.ncbi.nlm.nih.gov/pubmed/36875752
http://dx.doi.org/10.3389/fcell.2023.1143532
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author Chen, Xiao-Qiong
Shen, Tao
Fang, Shao-Jun
Sun, Xiao-Min
Li, Guo-Yu
Li, Yun-Feng
author_facet Chen, Xiao-Qiong
Shen, Tao
Fang, Shao-Jun
Sun, Xiao-Min
Li, Guo-Yu
Li, Yun-Feng
author_sort Chen, Xiao-Qiong
collection PubMed
description Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals. In this review, we summarize the regulatory mechanisms of proteostasis and discuss the relationship between proteostasis and aging and age-related diseases, including cancer. Furthermore, we highlight the clinical application value of proteostasis maintenance in delaying the aging process and promoting long-term health.
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spelling pubmed-99784022023-03-03 Protein homeostasis in aging and cancer Chen, Xiao-Qiong Shen, Tao Fang, Shao-Jun Sun, Xiao-Min Li, Guo-Yu Li, Yun-Feng Front Cell Dev Biol Cell and Developmental Biology Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals. In this review, we summarize the regulatory mechanisms of proteostasis and discuss the relationship between proteostasis and aging and age-related diseases, including cancer. Furthermore, we highlight the clinical application value of proteostasis maintenance in delaying the aging process and promoting long-term health. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978402/ /pubmed/36875752 http://dx.doi.org/10.3389/fcell.2023.1143532 Text en Copyright © 2023 Chen, Shen, Fang, Sun, Li and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Xiao-Qiong
Shen, Tao
Fang, Shao-Jun
Sun, Xiao-Min
Li, Guo-Yu
Li, Yun-Feng
Protein homeostasis in aging and cancer
title Protein homeostasis in aging and cancer
title_full Protein homeostasis in aging and cancer
title_fullStr Protein homeostasis in aging and cancer
title_full_unstemmed Protein homeostasis in aging and cancer
title_short Protein homeostasis in aging and cancer
title_sort protein homeostasis in aging and cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978402/
https://www.ncbi.nlm.nih.gov/pubmed/36875752
http://dx.doi.org/10.3389/fcell.2023.1143532
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AT liyunfeng proteinhomeostasisinagingandcancer

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