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Interconnected sub-networks of the macaque monkey gustatory connectome

Macroscopic taste processing connectivity was investigated using functional magnetic resonance imaging during the presentation of sour, salty, and sweet tastants in anesthetized macaque monkeys. This examination of taste processing affords the opportunity to study the interactions between sensory re...

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Autores principales: Hartig, Renée, Karimi, Ali, Evrard, Henry C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978403/
https://www.ncbi.nlm.nih.gov/pubmed/36874640
http://dx.doi.org/10.3389/fnins.2022.818800
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author Hartig, Renée
Karimi, Ali
Evrard, Henry C.
author_facet Hartig, Renée
Karimi, Ali
Evrard, Henry C.
author_sort Hartig, Renée
collection PubMed
description Macroscopic taste processing connectivity was investigated using functional magnetic resonance imaging during the presentation of sour, salty, and sweet tastants in anesthetized macaque monkeys. This examination of taste processing affords the opportunity to study the interactions between sensory regions, central integrators, and effector areas. Here, 58 brain regions associated with gustatory processing in primates were aggregated, collectively forming the gustatory connectome. Regional regression coefficients (or β-series) obtained during taste stimulation were correlated to infer functional connectivity. This connectivity was then evaluated by assessing its laterality, modularity and centrality. Our results indicate significant correlations between same region pairs across hemispheres in a bilaterally interconnected scheme for taste processing throughout the gustatory connectome. Using unbiased community detection, three bilateral sub-networks were detected within the graph of the connectome. This analysis revealed clustering of 16 medial cortical structures, 24 lateral structures, and 18 subcortical structures. Across the three sub-networks, a similar pattern was observed in the differential processing of taste qualities. In all cases, the amplitude of the response was greatest for sweet, but the network connectivity was strongest for sour and salty tastants. The importance of each region in taste processing was computed using node centrality measures within the connectome graph, showing centrality to be correlated across hemispheres and, to a smaller extent, region volume. Connectome hubs exhibited varying degrees of centrality with a prominent leftward increase in insular cortex centrality. Taken together, these criteria illustrate quantifiable characteristics of the macaque monkey gustatory connectome and its organization as a tri-modular network, which may reflect the general medial-lateral-subcortical organization of salience and interoception processing networks.
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spelling pubmed-99784032023-03-03 Interconnected sub-networks of the macaque monkey gustatory connectome Hartig, Renée Karimi, Ali Evrard, Henry C. Front Neurosci Neuroscience Macroscopic taste processing connectivity was investigated using functional magnetic resonance imaging during the presentation of sour, salty, and sweet tastants in anesthetized macaque monkeys. This examination of taste processing affords the opportunity to study the interactions between sensory regions, central integrators, and effector areas. Here, 58 brain regions associated with gustatory processing in primates were aggregated, collectively forming the gustatory connectome. Regional regression coefficients (or β-series) obtained during taste stimulation were correlated to infer functional connectivity. This connectivity was then evaluated by assessing its laterality, modularity and centrality. Our results indicate significant correlations between same region pairs across hemispheres in a bilaterally interconnected scheme for taste processing throughout the gustatory connectome. Using unbiased community detection, three bilateral sub-networks were detected within the graph of the connectome. This analysis revealed clustering of 16 medial cortical structures, 24 lateral structures, and 18 subcortical structures. Across the three sub-networks, a similar pattern was observed in the differential processing of taste qualities. In all cases, the amplitude of the response was greatest for sweet, but the network connectivity was strongest for sour and salty tastants. The importance of each region in taste processing was computed using node centrality measures within the connectome graph, showing centrality to be correlated across hemispheres and, to a smaller extent, region volume. Connectome hubs exhibited varying degrees of centrality with a prominent leftward increase in insular cortex centrality. Taken together, these criteria illustrate quantifiable characteristics of the macaque monkey gustatory connectome and its organization as a tri-modular network, which may reflect the general medial-lateral-subcortical organization of salience and interoception processing networks. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978403/ /pubmed/36874640 http://dx.doi.org/10.3389/fnins.2022.818800 Text en Copyright © 2023 Hartig, Karimi and Evrard. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hartig, Renée
Karimi, Ali
Evrard, Henry C.
Interconnected sub-networks of the macaque monkey gustatory connectome
title Interconnected sub-networks of the macaque monkey gustatory connectome
title_full Interconnected sub-networks of the macaque monkey gustatory connectome
title_fullStr Interconnected sub-networks of the macaque monkey gustatory connectome
title_full_unstemmed Interconnected sub-networks of the macaque monkey gustatory connectome
title_short Interconnected sub-networks of the macaque monkey gustatory connectome
title_sort interconnected sub-networks of the macaque monkey gustatory connectome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978403/
https://www.ncbi.nlm.nih.gov/pubmed/36874640
http://dx.doi.org/10.3389/fnins.2022.818800
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