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An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin

Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity. Although BAT is the opposite of white adipose tissue (WAT) which is responsible for energy storage, BAT shares thermogenic capacity with bei...

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Autores principales: Ziqubu, Khanyisani, Dludla, Phiwayinkosi V., Mthembu, Sinenhlanhla X. H., Nkambule, Bongani B., Mabhida, Sihle E., Jack, Babalwa U., Nyambuya, Tawanda M., Mazibuko-Mbeje, Sithandiwe E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978510/
https://www.ncbi.nlm.nih.gov/pubmed/36875450
http://dx.doi.org/10.3389/fendo.2023.1114767
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author Ziqubu, Khanyisani
Dludla, Phiwayinkosi V.
Mthembu, Sinenhlanhla X. H.
Nkambule, Bongani B.
Mabhida, Sihle E.
Jack, Babalwa U.
Nyambuya, Tawanda M.
Mazibuko-Mbeje, Sithandiwe E.
author_facet Ziqubu, Khanyisani
Dludla, Phiwayinkosi V.
Mthembu, Sinenhlanhla X. H.
Nkambule, Bongani B.
Mabhida, Sihle E.
Jack, Babalwa U.
Nyambuya, Tawanda M.
Mazibuko-Mbeje, Sithandiwe E.
author_sort Ziqubu, Khanyisani
collection PubMed
description Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity. Although BAT is the opposite of white adipose tissue (WAT) which is responsible for energy storage, BAT shares thermogenic capacity with beige adipose tissue that emerges from WAT depots. This is unsurprising as both BAT and beige adipose tissue display a huge difference from WAT in terms of their secretory profile and physiological role. In obesity, the content of BAT and beige adipose tissue declines as these tissues acquire the WAT characteristics via the process called “whitening”. This process has been rarely explored for its implication in obesity, whether it contributes to or exacerbates obesity. Emerging research has demonstrated that BAT/beige adipose tissue whitening is a sophisticated metabolic complication of obesity that is linked to multiple factors. The current review provides clarification on the influence of various factors such as diet, age, genetics, thermoneutrality, and chemical exposure on BAT/beige adipose tissue whitening. Moreover, the defects and mechanisms that underpin the whitening are described. Notably, the BAT/beige adipose tissue whitening can be marked by the accumulation of large unilocular lipid droplets, mitochondrial degeneration, and collapsed thermogenic capacity, by the virtue of mitochondrial dysfunction, devascularization, autophagy, and inflammation.
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spelling pubmed-99785102023-03-03 An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin Ziqubu, Khanyisani Dludla, Phiwayinkosi V. Mthembu, Sinenhlanhla X. H. Nkambule, Bongani B. Mabhida, Sihle E. Jack, Babalwa U. Nyambuya, Tawanda M. Mazibuko-Mbeje, Sithandiwe E. Front Endocrinol (Lausanne) Endocrinology Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity. Although BAT is the opposite of white adipose tissue (WAT) which is responsible for energy storage, BAT shares thermogenic capacity with beige adipose tissue that emerges from WAT depots. This is unsurprising as both BAT and beige adipose tissue display a huge difference from WAT in terms of their secretory profile and physiological role. In obesity, the content of BAT and beige adipose tissue declines as these tissues acquire the WAT characteristics via the process called “whitening”. This process has been rarely explored for its implication in obesity, whether it contributes to or exacerbates obesity. Emerging research has demonstrated that BAT/beige adipose tissue whitening is a sophisticated metabolic complication of obesity that is linked to multiple factors. The current review provides clarification on the influence of various factors such as diet, age, genetics, thermoneutrality, and chemical exposure on BAT/beige adipose tissue whitening. Moreover, the defects and mechanisms that underpin the whitening are described. Notably, the BAT/beige adipose tissue whitening can be marked by the accumulation of large unilocular lipid droplets, mitochondrial degeneration, and collapsed thermogenic capacity, by the virtue of mitochondrial dysfunction, devascularization, autophagy, and inflammation. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978510/ /pubmed/36875450 http://dx.doi.org/10.3389/fendo.2023.1114767 Text en Copyright © 2023 Ziqubu, Dludla, Mthembu, Nkambule, Mabhida, Jack, Nyambuya and Mazibuko-Mbeje https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ziqubu, Khanyisani
Dludla, Phiwayinkosi V.
Mthembu, Sinenhlanhla X. H.
Nkambule, Bongani B.
Mabhida, Sihle E.
Jack, Babalwa U.
Nyambuya, Tawanda M.
Mazibuko-Mbeje, Sithandiwe E.
An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
title An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
title_full An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
title_fullStr An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
title_full_unstemmed An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
title_short An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
title_sort insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978510/
https://www.ncbi.nlm.nih.gov/pubmed/36875450
http://dx.doi.org/10.3389/fendo.2023.1114767
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