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New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment

Characterized by psychotic symptoms, negative symptoms and cognitive deficits, schizophrenia had a catastrophic effect on patients and their families. Multifaceted reliable evidence indicated that schizophrenia is a neurodevelopmental disorder. Microglia, the immune cells in central nervous system,...

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Detalles Bibliográficos
Autores principales: Li, Jingjing, Wang, Yu, Yuan, Xiuxia, Kang, Yulin, Song, Xueqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978517/
https://www.ncbi.nlm.nih.gov/pubmed/36873215
http://dx.doi.org/10.3389/fpsyt.2023.1126632
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author Li, Jingjing
Wang, Yu
Yuan, Xiuxia
Kang, Yulin
Song, Xueqin
author_facet Li, Jingjing
Wang, Yu
Yuan, Xiuxia
Kang, Yulin
Song, Xueqin
author_sort Li, Jingjing
collection PubMed
description Characterized by psychotic symptoms, negative symptoms and cognitive deficits, schizophrenia had a catastrophic effect on patients and their families. Multifaceted reliable evidence indicated that schizophrenia is a neurodevelopmental disorder. Microglia, the immune cells in central nervous system, related to many neurodevelopmental diseases. Microglia could affect neuronal survival, neuronal death and synaptic plasticity during neurodevelopment. Anomalous microglia during neurodevelopment may be associated with schizophrenia. Therefore, a hypothesis proposes that the abnormal function of microglia leads to the occurrence of schizophrenia. Nowadays, accumulating experiments between microglia and schizophrenia could afford unparalleled probability to assess this hypothesis. Herein, this review summarizes the latest supporting evidence in order to shed light on the mystery of microglia in schizophrenia.
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spelling pubmed-99785172023-03-03 New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment Li, Jingjing Wang, Yu Yuan, Xiuxia Kang, Yulin Song, Xueqin Front Psychiatry Psychiatry Characterized by psychotic symptoms, negative symptoms and cognitive deficits, schizophrenia had a catastrophic effect on patients and their families. Multifaceted reliable evidence indicated that schizophrenia is a neurodevelopmental disorder. Microglia, the immune cells in central nervous system, related to many neurodevelopmental diseases. Microglia could affect neuronal survival, neuronal death and synaptic plasticity during neurodevelopment. Anomalous microglia during neurodevelopment may be associated with schizophrenia. Therefore, a hypothesis proposes that the abnormal function of microglia leads to the occurrence of schizophrenia. Nowadays, accumulating experiments between microglia and schizophrenia could afford unparalleled probability to assess this hypothesis. Herein, this review summarizes the latest supporting evidence in order to shed light on the mystery of microglia in schizophrenia. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978517/ /pubmed/36873215 http://dx.doi.org/10.3389/fpsyt.2023.1126632 Text en Copyright © 2023 Li, Wang, Yuan, Kang and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Li, Jingjing
Wang, Yu
Yuan, Xiuxia
Kang, Yulin
Song, Xueqin
New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment
title New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment
title_full New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment
title_fullStr New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment
title_full_unstemmed New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment
title_short New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment
title_sort new insight in the cross-talk between microglia and schizophrenia: from the perspective of neurodevelopment
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978517/
https://www.ncbi.nlm.nih.gov/pubmed/36873215
http://dx.doi.org/10.3389/fpsyt.2023.1126632
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