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The immunotherapy advancement targeting malignant blastomas in early childhood

Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment...

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Detalles Bibliográficos
Autores principales: Zang, Bolun, Ding, Luyue, Liu, Linlin, Arun Kumar, Senthil, Liu, Wei, Zhou, Chongchen, Duan, Yongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978522/
https://www.ncbi.nlm.nih.gov/pubmed/36874100
http://dx.doi.org/10.3389/fonc.2023.1015115
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author Zang, Bolun
Ding, Luyue
Liu, Linlin
Arun Kumar, Senthil
Liu, Wei
Zhou, Chongchen
Duan, Yongtao
author_facet Zang, Bolun
Ding, Luyue
Liu, Linlin
Arun Kumar, Senthil
Liu, Wei
Zhou, Chongchen
Duan, Yongtao
author_sort Zang, Bolun
collection PubMed
description Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment types (surgery, radiotherapy, and chemotherapy) showed promise or were effective in treating malignant blastomas among child patients. N ew, innovative immunotherapeutic procedures including monoclonal antibodies and chimeric-antigen based receptor (CAR) cell therapy, coupled with the clinical study of reliable therapeutic targets and immune regulatory pathways targeting malignant blastomas, have attracted the attention of clinicians recently.
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spelling pubmed-99785222023-03-03 The immunotherapy advancement targeting malignant blastomas in early childhood Zang, Bolun Ding, Luyue Liu, Linlin Arun Kumar, Senthil Liu, Wei Zhou, Chongchen Duan, Yongtao Front Oncol Oncology Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment types (surgery, radiotherapy, and chemotherapy) showed promise or were effective in treating malignant blastomas among child patients. N ew, innovative immunotherapeutic procedures including monoclonal antibodies and chimeric-antigen based receptor (CAR) cell therapy, coupled with the clinical study of reliable therapeutic targets and immune regulatory pathways targeting malignant blastomas, have attracted the attention of clinicians recently. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978522/ /pubmed/36874100 http://dx.doi.org/10.3389/fonc.2023.1015115 Text en Copyright © 2023 Zang, Ding, Liu, Arun Kumar, Liu, Zhou and Duan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zang, Bolun
Ding, Luyue
Liu, Linlin
Arun Kumar, Senthil
Liu, Wei
Zhou, Chongchen
Duan, Yongtao
The immunotherapy advancement targeting malignant blastomas in early childhood
title The immunotherapy advancement targeting malignant blastomas in early childhood
title_full The immunotherapy advancement targeting malignant blastomas in early childhood
title_fullStr The immunotherapy advancement targeting malignant blastomas in early childhood
title_full_unstemmed The immunotherapy advancement targeting malignant blastomas in early childhood
title_short The immunotherapy advancement targeting malignant blastomas in early childhood
title_sort immunotherapy advancement targeting malignant blastomas in early childhood
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978522/
https://www.ncbi.nlm.nih.gov/pubmed/36874100
http://dx.doi.org/10.3389/fonc.2023.1015115
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