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The immunotherapy advancement targeting malignant blastomas in early childhood
Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978522/ https://www.ncbi.nlm.nih.gov/pubmed/36874100 http://dx.doi.org/10.3389/fonc.2023.1015115 |
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author | Zang, Bolun Ding, Luyue Liu, Linlin Arun Kumar, Senthil Liu, Wei Zhou, Chongchen Duan, Yongtao |
author_facet | Zang, Bolun Ding, Luyue Liu, Linlin Arun Kumar, Senthil Liu, Wei Zhou, Chongchen Duan, Yongtao |
author_sort | Zang, Bolun |
collection | PubMed |
description | Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment types (surgery, radiotherapy, and chemotherapy) showed promise or were effective in treating malignant blastomas among child patients. N ew, innovative immunotherapeutic procedures including monoclonal antibodies and chimeric-antigen based receptor (CAR) cell therapy, coupled with the clinical study of reliable therapeutic targets and immune regulatory pathways targeting malignant blastomas, have attracted the attention of clinicians recently. |
format | Online Article Text |
id | pubmed-9978522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99785222023-03-03 The immunotherapy advancement targeting malignant blastomas in early childhood Zang, Bolun Ding, Luyue Liu, Linlin Arun Kumar, Senthil Liu, Wei Zhou, Chongchen Duan, Yongtao Front Oncol Oncology Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment types (surgery, radiotherapy, and chemotherapy) showed promise or were effective in treating malignant blastomas among child patients. N ew, innovative immunotherapeutic procedures including monoclonal antibodies and chimeric-antigen based receptor (CAR) cell therapy, coupled with the clinical study of reliable therapeutic targets and immune regulatory pathways targeting malignant blastomas, have attracted the attention of clinicians recently. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978522/ /pubmed/36874100 http://dx.doi.org/10.3389/fonc.2023.1015115 Text en Copyright © 2023 Zang, Ding, Liu, Arun Kumar, Liu, Zhou and Duan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zang, Bolun Ding, Luyue Liu, Linlin Arun Kumar, Senthil Liu, Wei Zhou, Chongchen Duan, Yongtao The immunotherapy advancement targeting malignant blastomas in early childhood |
title | The immunotherapy advancement targeting malignant blastomas in early childhood |
title_full | The immunotherapy advancement targeting malignant blastomas in early childhood |
title_fullStr | The immunotherapy advancement targeting malignant blastomas in early childhood |
title_full_unstemmed | The immunotherapy advancement targeting malignant blastomas in early childhood |
title_short | The immunotherapy advancement targeting malignant blastomas in early childhood |
title_sort | immunotherapy advancement targeting malignant blastomas in early childhood |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978522/ https://www.ncbi.nlm.nih.gov/pubmed/36874100 http://dx.doi.org/10.3389/fonc.2023.1015115 |
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