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Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection
Travelers to Chagas disease endemic regions of Latin America may be at risk for Trypanosoma cruzi infection. We report a 67-year-old woman who screened positive for T. cruzi infection while donating blood. The patient had a history of an unusual febrile illness and marked swelling of the face sustai...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The American Society of Tropical Medicine and Hygiene
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978553/ https://www.ncbi.nlm.nih.gov/pubmed/36646072 http://dx.doi.org/10.4269/ajtmh.22-0461 |
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author | Beatty, Norman L. Alcala, Rodrigo F. Luque, Nelson A. Radetic, Mark Joshi-Guske, Priti Alakrad, Eyad Forsyth, Colin J. Hamer, Davidson H. |
author_facet | Beatty, Norman L. Alcala, Rodrigo F. Luque, Nelson A. Radetic, Mark Joshi-Guske, Priti Alakrad, Eyad Forsyth, Colin J. Hamer, Davidson H. |
author_sort | Beatty, Norman L. |
collection | PubMed |
description | Travelers to Chagas disease endemic regions of Latin America may be at risk for Trypanosoma cruzi infection. We report a 67-year-old woman who screened positive for T. cruzi infection while donating blood. The patient had a history of an unusual febrile illness and marked swelling of the face sustained at age 10 after camping in northern Mexico that led to a 3-week hospitalization without a diagnosis. More than 4 decades later, rapid diagnostic tests and commercial and confirmatory serology for Chagas disease were all positive for T. cruzi infection. On evaluation, the patient described a progressive chronic cough, gastroesophageal reflux, and dysphagia for > 10 years. There was no evidence of any cardiac complications. However, esophageal manometry demonstrated significant dysmotility, with 90% of swallows being ineffective with evidence of esophageal pressurization and retrograde peristalsis in several swallows, suggesting early autonomic disruption due to Chagas disease esophagopathy. In this report, we highlight the importance of travel-related Chagas disease among travelers to endemic regions and the need to further identify potential risks of transmission among this at-risk population. |
format | Online Article Text |
id | pubmed-9978553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-99785532023-03-03 Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection Beatty, Norman L. Alcala, Rodrigo F. Luque, Nelson A. Radetic, Mark Joshi-Guske, Priti Alakrad, Eyad Forsyth, Colin J. Hamer, Davidson H. Am J Trop Med Hyg Case Report Travelers to Chagas disease endemic regions of Latin America may be at risk for Trypanosoma cruzi infection. We report a 67-year-old woman who screened positive for T. cruzi infection while donating blood. The patient had a history of an unusual febrile illness and marked swelling of the face sustained at age 10 after camping in northern Mexico that led to a 3-week hospitalization without a diagnosis. More than 4 decades later, rapid diagnostic tests and commercial and confirmatory serology for Chagas disease were all positive for T. cruzi infection. On evaluation, the patient described a progressive chronic cough, gastroesophageal reflux, and dysphagia for > 10 years. There was no evidence of any cardiac complications. However, esophageal manometry demonstrated significant dysmotility, with 90% of swallows being ineffective with evidence of esophageal pressurization and retrograde peristalsis in several swallows, suggesting early autonomic disruption due to Chagas disease esophagopathy. In this report, we highlight the importance of travel-related Chagas disease among travelers to endemic regions and the need to further identify potential risks of transmission among this at-risk population. The American Society of Tropical Medicine and Hygiene 2023-03 2023-01-16 /pmc/articles/PMC9978553/ /pubmed/36646072 http://dx.doi.org/10.4269/ajtmh.22-0461 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Beatty, Norman L. Alcala, Rodrigo F. Luque, Nelson A. Radetic, Mark Joshi-Guske, Priti Alakrad, Eyad Forsyth, Colin J. Hamer, Davidson H. Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection |
title | Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection |
title_full | Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection |
title_fullStr | Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection |
title_full_unstemmed | Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection |
title_short | Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection |
title_sort | case report: chagas disease in a traveler who developed esophageal involvement decades after acute infection |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978553/ https://www.ncbi.nlm.nih.gov/pubmed/36646072 http://dx.doi.org/10.4269/ajtmh.22-0461 |
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