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Establishment of a core outcome set for burn care research: development and international consensus

OBJECTIVE: To develop a core outcome set for international burn research. DESIGN: Development and international consensus, from April 2017 to November 2019. METHODS: Candidate outcomes were identified from systematic reviews and stakeholder interviews. Through a Delphi survey, international clinicia...

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Autores principales: Young, Amber, Davies, Anna, Tsang, Carmen, Kirkham, Jamie, Potokar, Tom, Gibran, Nicole, Tyack, Zephanie, Meirte, Jill, Harada, Teruichi, Dheansa, Baljit, Dumville, Jo, Metcalfe, Chris, Ahuja, Rajeev, Wood, Fiona, Gaskell, Sarah, Brookes, Sara, Smailes, Sarah, Jeschke, Marc, Cinar, Murat Ali, Zia, Nukhba, Moghazy, Amr, Mathers, Jonathan, Falder, Sian, Edgar, Dale, Blazeby, Jane Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978679/
https://www.ncbi.nlm.nih.gov/pubmed/36936572
http://dx.doi.org/10.1136/bmjmed-2022-000183
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author Young, Amber
Davies, Anna
Tsang, Carmen
Kirkham, Jamie
Potokar, Tom
Gibran, Nicole
Tyack, Zephanie
Meirte, Jill
Harada, Teruichi
Dheansa, Baljit
Dumville, Jo
Metcalfe, Chris
Ahuja, Rajeev
Wood, Fiona
Gaskell, Sarah
Brookes, Sara
Smailes, Sarah
Jeschke, Marc
Cinar, Murat Ali
Zia, Nukhba
Moghazy, Amr
Mathers, Jonathan
Falder, Sian
Edgar, Dale
Blazeby, Jane Mary
author_facet Young, Amber
Davies, Anna
Tsang, Carmen
Kirkham, Jamie
Potokar, Tom
Gibran, Nicole
Tyack, Zephanie
Meirte, Jill
Harada, Teruichi
Dheansa, Baljit
Dumville, Jo
Metcalfe, Chris
Ahuja, Rajeev
Wood, Fiona
Gaskell, Sarah
Brookes, Sara
Smailes, Sarah
Jeschke, Marc
Cinar, Murat Ali
Zia, Nukhba
Moghazy, Amr
Mathers, Jonathan
Falder, Sian
Edgar, Dale
Blazeby, Jane Mary
author_sort Young, Amber
collection PubMed
description OBJECTIVE: To develop a core outcome set for international burn research. DESIGN: Development and international consensus, from April 2017 to November 2019. METHODS: Candidate outcomes were identified from systematic reviews and stakeholder interviews. Through a Delphi survey, international clinicians, researchers, and UK patients prioritised outcomes. Anonymised feedback aimed to achieve consensus. Pre-defined criteria for retaining outcomes were agreed. A consensus meeting with voting was held to finalise the core outcome set. RESULTS: Data source examination identified 1021 unique outcomes grouped into 88 candidate outcomes. Stakeholders in round 1 of the survey, included 668 health professionals from 77 countries (18% from low or low middle income countries) and 126 UK patients or carers. After round 1, one outcome was discarded, and 13 new outcomes added. After round 2, 69 items were discarded, leaving 31 outcomes for the consensus meeting. Outcome merging and voting, in two rounds, with prespecified thresholds agreed seven core outcomes: death, specified complications, ability to do daily tasks, wound healing, neuropathic pain and itch, psychological wellbeing, and return to school or work. CONCLUSIONS: This core outcome set caters for global burn research, and future trials are recommended to include measures of these outcomes.
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spelling pubmed-99786792023-03-16 Establishment of a core outcome set for burn care research: development and international consensus Young, Amber Davies, Anna Tsang, Carmen Kirkham, Jamie Potokar, Tom Gibran, Nicole Tyack, Zephanie Meirte, Jill Harada, Teruichi Dheansa, Baljit Dumville, Jo Metcalfe, Chris Ahuja, Rajeev Wood, Fiona Gaskell, Sarah Brookes, Sara Smailes, Sarah Jeschke, Marc Cinar, Murat Ali Zia, Nukhba Moghazy, Amr Mathers, Jonathan Falder, Sian Edgar, Dale Blazeby, Jane Mary BMJ Med Research OBJECTIVE: To develop a core outcome set for international burn research. DESIGN: Development and international consensus, from April 2017 to November 2019. METHODS: Candidate outcomes were identified from systematic reviews and stakeholder interviews. Through a Delphi survey, international clinicians, researchers, and UK patients prioritised outcomes. Anonymised feedback aimed to achieve consensus. Pre-defined criteria for retaining outcomes were agreed. A consensus meeting with voting was held to finalise the core outcome set. RESULTS: Data source examination identified 1021 unique outcomes grouped into 88 candidate outcomes. Stakeholders in round 1 of the survey, included 668 health professionals from 77 countries (18% from low or low middle income countries) and 126 UK patients or carers. After round 1, one outcome was discarded, and 13 new outcomes added. After round 2, 69 items were discarded, leaving 31 outcomes for the consensus meeting. Outcome merging and voting, in two rounds, with prespecified thresholds agreed seven core outcomes: death, specified complications, ability to do daily tasks, wound healing, neuropathic pain and itch, psychological wellbeing, and return to school or work. CONCLUSIONS: This core outcome set caters for global burn research, and future trials are recommended to include measures of these outcomes. BMJ Publishing Group 2022-07-07 /pmc/articles/PMC9978679/ /pubmed/36936572 http://dx.doi.org/10.1136/bmjmed-2022-000183 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research
Young, Amber
Davies, Anna
Tsang, Carmen
Kirkham, Jamie
Potokar, Tom
Gibran, Nicole
Tyack, Zephanie
Meirte, Jill
Harada, Teruichi
Dheansa, Baljit
Dumville, Jo
Metcalfe, Chris
Ahuja, Rajeev
Wood, Fiona
Gaskell, Sarah
Brookes, Sara
Smailes, Sarah
Jeschke, Marc
Cinar, Murat Ali
Zia, Nukhba
Moghazy, Amr
Mathers, Jonathan
Falder, Sian
Edgar, Dale
Blazeby, Jane Mary
Establishment of a core outcome set for burn care research: development and international consensus
title Establishment of a core outcome set for burn care research: development and international consensus
title_full Establishment of a core outcome set for burn care research: development and international consensus
title_fullStr Establishment of a core outcome set for burn care research: development and international consensus
title_full_unstemmed Establishment of a core outcome set for burn care research: development and international consensus
title_short Establishment of a core outcome set for burn care research: development and international consensus
title_sort establishment of a core outcome set for burn care research: development and international consensus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978679/
https://www.ncbi.nlm.nih.gov/pubmed/36936572
http://dx.doi.org/10.1136/bmjmed-2022-000183
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