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Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway
Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) ant...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978827/ https://www.ncbi.nlm.nih.gov/pubmed/36875839 http://dx.doi.org/10.3389/fnut.2023.1102146 |
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author | Luo, Jiang-Hong Li, Jing Shen, Zi-Chun Lin, Xiao-Fan Chen, Ao-Qiu Wang, Yi-Fei Gong, Er-Sheng Liu, Dan Zou, Qi Wang, Xiao-Yin |
author_facet | Luo, Jiang-Hong Li, Jing Shen, Zi-Chun Lin, Xiao-Fan Chen, Ao-Qiu Wang, Yi-Fei Gong, Er-Sheng Liu, Dan Zou, Qi Wang, Xiao-Yin |
author_sort | Luo, Jiang-Hong |
collection | PubMed |
description | Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important endogenous antioxidant pathway, which plays crucial roles in maintaining human health as its protection against oxidative stress. Accumulating evidence suggested that Nrf2 antioxidant pathway might be one of key regulatory targets for the health-promoting effects of NPs. However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes. Therefore, in this article, structural features of NPs having regulation on Nrf2 antioxidant pathway are overviewed. Moreover, regulatory effects of NPs on this pathway for health-promoting effects are summarized. Furthermore, structure-activity relationship of NPs for health-promoting effects by regulating the pathway is preliminarily discussed. Otherwise, the prospects on future work for regulation of NPs on this pathway are proposed. This review is beneficial to well-understanding of underlying mechanisms for health-promoting effects of NPs from the view angle of Nrf2 antioxidant pathway, and provides a theoretical basis for the development and utilization of NPs in promoting human health. |
format | Online Article Text |
id | pubmed-9978827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99788272023-03-03 Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway Luo, Jiang-Hong Li, Jing Shen, Zi-Chun Lin, Xiao-Fan Chen, Ao-Qiu Wang, Yi-Fei Gong, Er-Sheng Liu, Dan Zou, Qi Wang, Xiao-Yin Front Nutr Nutrition Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important endogenous antioxidant pathway, which plays crucial roles in maintaining human health as its protection against oxidative stress. Accumulating evidence suggested that Nrf2 antioxidant pathway might be one of key regulatory targets for the health-promoting effects of NPs. However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes. Therefore, in this article, structural features of NPs having regulation on Nrf2 antioxidant pathway are overviewed. Moreover, regulatory effects of NPs on this pathway for health-promoting effects are summarized. Furthermore, structure-activity relationship of NPs for health-promoting effects by regulating the pathway is preliminarily discussed. Otherwise, the prospects on future work for regulation of NPs on this pathway are proposed. This review is beneficial to well-understanding of underlying mechanisms for health-promoting effects of NPs from the view angle of Nrf2 antioxidant pathway, and provides a theoretical basis for the development and utilization of NPs in promoting human health. Frontiers Media S.A. 2023-02-16 /pmc/articles/PMC9978827/ /pubmed/36875839 http://dx.doi.org/10.3389/fnut.2023.1102146 Text en Copyright © 2023 Luo, Li, Shen, Lin, Chen, Wang, Gong, Liu, Zou and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Luo, Jiang-Hong Li, Jing Shen, Zi-Chun Lin, Xiao-Fan Chen, Ao-Qiu Wang, Yi-Fei Gong, Er-Sheng Liu, Dan Zou, Qi Wang, Xiao-Yin Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway |
title | Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway |
title_full | Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway |
title_fullStr | Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway |
title_full_unstemmed | Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway |
title_short | Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway |
title_sort | advances in health-promoting effects of natural polysaccharides: regulation on nrf2 antioxidant pathway |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978827/ https://www.ncbi.nlm.nih.gov/pubmed/36875839 http://dx.doi.org/10.3389/fnut.2023.1102146 |
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