Mesenchymal Stem Cells Ameliorate Fibrosis by Enhancing Autophagy via Inhibiting Galectin-3/Akt/mTOR Pathway and by Alleviating the EMT via Inhibiting Galectin-3/Akt/GSK3β/Snail Pathway in NRK-52E Fibrosis

BACKGROUND AND OBJECTIVES: Epithelial-Mesenchymal transition (EMT) is one of the origins of myofibroblasts in renal interstitial fibrosis. Mesenchymal stem cells (MSCs) alleviating EMT has been proved, but the concrete mechanism is unclear. To explore the mechanism, serum-free MSCs conditioned mediu...

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Detalles Bibliográficos
Autores principales: Zhao, Yu, Guo, Chuan, Zeng, Lianlin, Li, Jialing, Liu, Xia, Wang, Yiwei, Zhao, Kun, Chen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978829/
https://www.ncbi.nlm.nih.gov/pubmed/35483714
http://dx.doi.org/10.15283/ijsc22014

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