Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay

Rapid intrahepatic and distant metastasis of hepatocellular carcinoma (HCC) after locoregional treatment for early stage tumor is very rare. Descriptions of spontaneous regression of HCC exist in case reports, but its true mechanism is unclear. Here, we describe a case of rapid dissemination with lu...

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Autores principales: Xu, Yiqing, Bayewitz, Ashrei, Tary-Lehmann, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by S. Karger AG 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978950/
https://www.ncbi.nlm.nih.gov/pubmed/36876217
http://dx.doi.org/10.1159/000527229
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author Xu, Yiqing
Bayewitz, Ashrei
Tary-Lehmann, Magdalena
author_facet Xu, Yiqing
Bayewitz, Ashrei
Tary-Lehmann, Magdalena
author_sort Xu, Yiqing
collection PubMed
description Rapid intrahepatic and distant metastasis of hepatocellular carcinoma (HCC) after locoregional treatment for early stage tumor is very rare. Descriptions of spontaneous regression of HCC exist in case reports, but its true mechanism is unclear. Here, we describe a case of rapid dissemination with lung metastasis shortly after localized RFA treatment of HCC liver lesions, followed by spontaneous, sustained regression of those lung lesions. We also show the detection of cytotoxic T lymphocytes (CTLs) specific to hepatitis B antigens by immune assay in this patient. We propose immune-related destruction as the basis for spontaneous regression.
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spelling pubmed-99789502023-03-03 Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay Xu, Yiqing Bayewitz, Ashrei Tary-Lehmann, Magdalena Case Rep Oncol Case Report Rapid intrahepatic and distant metastasis of hepatocellular carcinoma (HCC) after locoregional treatment for early stage tumor is very rare. Descriptions of spontaneous regression of HCC exist in case reports, but its true mechanism is unclear. Here, we describe a case of rapid dissemination with lung metastasis shortly after localized RFA treatment of HCC liver lesions, followed by spontaneous, sustained regression of those lung lesions. We also show the detection of cytotoxic T lymphocytes (CTLs) specific to hepatitis B antigens by immune assay in this patient. We propose immune-related destruction as the basis for spontaneous regression. The Author(s). Published by S. Karger AG 2023-03-01 /pmc/articles/PMC9978950/ /pubmed/36876217 http://dx.doi.org/10.1159/000527229 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Xu, Yiqing
Bayewitz, Ashrei
Tary-Lehmann, Magdalena
Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay
title Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay
title_full Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay
title_fullStr Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay
title_full_unstemmed Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay
title_short Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay
title_sort rapid dissemination followed by spontaneous regression of metastatic hepatocellular carcinoma after liver radiofrequency thermal ablation: a case report with correlative immune assay
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978950/
https://www.ncbi.nlm.nih.gov/pubmed/36876217
http://dx.doi.org/10.1159/000527229
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AT bayewitzashrei rapiddisseminationfollowedbyspontaneousregressionofmetastatichepatocellularcarcinomaafterliverradiofrequencythermalablationacasereportwithcorrelativeimmuneassay
AT tarylehmannmagdalena rapiddisseminationfollowedbyspontaneousregressionofmetastatichepatocellularcarcinomaafterliverradiofrequencythermalablationacasereportwithcorrelativeimmuneassay

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