SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR

Farnesoid X receptor (FXR) is widely accepted as a promising target for various liver diseases; however, panels of ligands in drug development show limited clinical benefits, without a clear mechanism. Here, we reveal that acetylation initiates and orchestrates FXR nucleocytoplasmic shuttling and th...

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Detalles Bibliográficos
Autores principales: Cui, Shuang, Hu, Huijian, Chen, An, Cui, Ming, Pan, Xiaojie, Zhang, Pengfei, Wang, Guangji, Wang, Hong, Hao, Haiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978964/
https://www.ncbi.nlm.nih.gov/pubmed/36873184
http://dx.doi.org/10.1016/j.apsb.2022.08.019

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