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Design and construction of microbial cell factories based on systems biology

Environmental sustainability is an increasingly important issue in industry. As an environmentally friendly and sustainable way, constructing microbial cell factories to produce all kinds of valuable products has attracted more and more attention. In the process of constructing microbial cell factor...

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Detalles Bibliográficos
Autores principales: Yan, Wenlong, Cao, Zhibei, Ding, Mingzhu, Yuan, Yingjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979088/
https://www.ncbi.nlm.nih.gov/pubmed/36874510
http://dx.doi.org/10.1016/j.synbio.2022.11.001
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author Yan, Wenlong
Cao, Zhibei
Ding, Mingzhu
Yuan, Yingjin
author_facet Yan, Wenlong
Cao, Zhibei
Ding, Mingzhu
Yuan, Yingjin
author_sort Yan, Wenlong
collection PubMed
description Environmental sustainability is an increasingly important issue in industry. As an environmentally friendly and sustainable way, constructing microbial cell factories to produce all kinds of valuable products has attracted more and more attention. In the process of constructing microbial cell factories, systems biology plays a crucial role. This review summarizes the recent applications of systems biology in the design and construction of microbial cell factories from four perspectives, including functional genes/enzymes discovery, bottleneck pathways identification, strains tolerance improvement and design and construction of synthetic microbial consortia. Systems biology tools can be employed to identify functional genes/enzymes involved in the biosynthetic pathways of products. These discovered genes are introduced into appropriate chassis strains to build engineering microorganisms capable of producing products. Subsequently, systems biology tools are used to identify bottleneck pathways, improve strains tolerance and guide design and construction of synthetic microbial consortia, resulting in increasing the yield of engineered strains and constructing microbial cell factories successfully.
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spelling pubmed-99790882023-03-03 Design and construction of microbial cell factories based on systems biology Yan, Wenlong Cao, Zhibei Ding, Mingzhu Yuan, Yingjin Synth Syst Biotechnol Review Article Environmental sustainability is an increasingly important issue in industry. As an environmentally friendly and sustainable way, constructing microbial cell factories to produce all kinds of valuable products has attracted more and more attention. In the process of constructing microbial cell factories, systems biology plays a crucial role. This review summarizes the recent applications of systems biology in the design and construction of microbial cell factories from four perspectives, including functional genes/enzymes discovery, bottleneck pathways identification, strains tolerance improvement and design and construction of synthetic microbial consortia. Systems biology tools can be employed to identify functional genes/enzymes involved in the biosynthetic pathways of products. These discovered genes are introduced into appropriate chassis strains to build engineering microorganisms capable of producing products. Subsequently, systems biology tools are used to identify bottleneck pathways, improve strains tolerance and guide design and construction of synthetic microbial consortia, resulting in increasing the yield of engineered strains and constructing microbial cell factories successfully. KeAi Publishing 2022-11-18 /pmc/articles/PMC9979088/ /pubmed/36874510 http://dx.doi.org/10.1016/j.synbio.2022.11.001 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Yan, Wenlong
Cao, Zhibei
Ding, Mingzhu
Yuan, Yingjin
Design and construction of microbial cell factories based on systems biology
title Design and construction of microbial cell factories based on systems biology
title_full Design and construction of microbial cell factories based on systems biology
title_fullStr Design and construction of microbial cell factories based on systems biology
title_full_unstemmed Design and construction of microbial cell factories based on systems biology
title_short Design and construction of microbial cell factories based on systems biology
title_sort design and construction of microbial cell factories based on systems biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979088/
https://www.ncbi.nlm.nih.gov/pubmed/36874510
http://dx.doi.org/10.1016/j.synbio.2022.11.001
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