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BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a n...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979148/ https://www.ncbi.nlm.nih.gov/pubmed/36754625 http://dx.doi.org/10.1523/ENEURO.0257-22.2022 |
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author | Attokaren, Matthew K. Jeong, Nuri Blanpain, Lou Paulson, Abigail L. Garza, Kristie M. Borron, Ben Walelign, Michael Willie, Jon Singer, Annabelle C. |
author_facet | Attokaren, Matthew K. Jeong, Nuri Blanpain, Lou Paulson, Abigail L. Garza, Kristie M. Borron, Ben Walelign, Michael Willie, Jon Singer, Annabelle C. |
author_sort | Attokaren, Matthew K. |
collection | PubMed |
description | Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds (“flicker”). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel open-source methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species. |
format | Online Article Text |
id | pubmed-9979148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-99791482023-03-03 BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species Attokaren, Matthew K. Jeong, Nuri Blanpain, Lou Paulson, Abigail L. Garza, Kristie M. Borron, Ben Walelign, Michael Willie, Jon Singer, Annabelle C. eNeuro Open Source Tools and Methods Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds (“flicker”). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel open-source methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species. Society for Neuroscience 2023-02-23 /pmc/articles/PMC9979148/ /pubmed/36754625 http://dx.doi.org/10.1523/ENEURO.0257-22.2022 Text en Copyright © 2023 Attokaren et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Open Source Tools and Methods Attokaren, Matthew K. Jeong, Nuri Blanpain, Lou Paulson, Abigail L. Garza, Kristie M. Borron, Ben Walelign, Michael Willie, Jon Singer, Annabelle C. BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species |
title | BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species |
title_full | BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species |
title_fullStr | BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species |
title_full_unstemmed | BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species |
title_short | BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species |
title_sort | brainwave: a flexible method for noninvasive stimulation of brain rhythms across species |
topic | Open Source Tools and Methods |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979148/ https://www.ncbi.nlm.nih.gov/pubmed/36754625 http://dx.doi.org/10.1523/ENEURO.0257-22.2022 |
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