Cargando…

BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species

Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a n...

Descripción completa

Detalles Bibliográficos
Autores principales: Attokaren, Matthew K., Jeong, Nuri, Blanpain, Lou, Paulson, Abigail L., Garza, Kristie M., Borron, Ben, Walelign, Michael, Willie, Jon, Singer, Annabelle C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979148/
https://www.ncbi.nlm.nih.gov/pubmed/36754625
http://dx.doi.org/10.1523/ENEURO.0257-22.2022
_version_ 1784899666136006656
author Attokaren, Matthew K.
Jeong, Nuri
Blanpain, Lou
Paulson, Abigail L.
Garza, Kristie M.
Borron, Ben
Walelign, Michael
Willie, Jon
Singer, Annabelle C.
author_facet Attokaren, Matthew K.
Jeong, Nuri
Blanpain, Lou
Paulson, Abigail L.
Garza, Kristie M.
Borron, Ben
Walelign, Michael
Willie, Jon
Singer, Annabelle C.
author_sort Attokaren, Matthew K.
collection PubMed
description Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds (“flicker”). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel open-source methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species.
format Online
Article
Text
id pubmed-9979148
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Society for Neuroscience
record_format MEDLINE/PubMed
spelling pubmed-99791482023-03-03 BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species Attokaren, Matthew K. Jeong, Nuri Blanpain, Lou Paulson, Abigail L. Garza, Kristie M. Borron, Ben Walelign, Michael Willie, Jon Singer, Annabelle C. eNeuro Open Source Tools and Methods Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds (“flicker”). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel open-source methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species. Society for Neuroscience 2023-02-23 /pmc/articles/PMC9979148/ /pubmed/36754625 http://dx.doi.org/10.1523/ENEURO.0257-22.2022 Text en Copyright © 2023 Attokaren et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Open Source Tools and Methods
Attokaren, Matthew K.
Jeong, Nuri
Blanpain, Lou
Paulson, Abigail L.
Garza, Kristie M.
Borron, Ben
Walelign, Michael
Willie, Jon
Singer, Annabelle C.
BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
title BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
title_full BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
title_fullStr BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
title_full_unstemmed BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
title_short BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
title_sort brainwave: a flexible method for noninvasive stimulation of brain rhythms across species
topic Open Source Tools and Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979148/
https://www.ncbi.nlm.nih.gov/pubmed/36754625
http://dx.doi.org/10.1523/ENEURO.0257-22.2022
work_keys_str_mv AT attokarenmatthewk brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT jeongnuri brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT blanpainlou brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT paulsonabigaill brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT garzakristiem brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT borronben brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT walelignmichael brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT williejon brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies
AT singerannabellec brainwaveaflexiblemethodfornoninvasivestimulationofbrainrhythmsacrossspecies