Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients

AIM: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. METHODS: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA. RESULTS: Angiopoietin-2 levels elevated according to the s...

Descripción completa

Detalles Bibliográficos
Autores principales: Thanh Duyen, Luu Thi, Manh, Bui Van, Phuong Thao, Tran Thi, Khanh, Le Van, Linh Trang, Bui Ngoc, Giang, Ngo Truong, Quang, Ha Van, Viet, Nguyen Thanh, Hang, Ngo Thu, Mao, Can Van, Toan, Nguyen Linh, Tong, Hoang Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979161/
https://www.ncbi.nlm.nih.gov/pubmed/36874368
http://dx.doi.org/10.2144/fsoa-2022-0077
Descripción
Sumario:AIM: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. METHODS: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA. RESULTS: Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778). CONCLUSION: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.

Ejemplares similares