Cargando…
Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes
The prevalence of juvenile obesity is increasing, reaching epidemic proportions, presenting a link not only to NAFLD (non-alcoholic fatty liver disease) but to abnormal lipid profiles and liver enzyme abnormalities. Liver ultrasonography is a sensitive and specific tool for the recognition of NAFLD....
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979179/ https://www.ncbi.nlm.nih.gov/pubmed/36873135 http://dx.doi.org/10.25122/jml-2022-0091 |
_version_ | 1784899672926584832 |
---|---|
author | Altalebi, Raghid Reyadh Al-hussaniy, Hany Akeel Al-tameemi, Zahraa Salam AL-Zobaidy, Mohammed Abdul-Hassan Albu-Rghaif, Ali Hikmat Alkuraishy, Hayder Mutter Hedeab, Gomaa Mostafa Azam, Faizul Al-Samydai, Ali Mahmoud Naji, Meena Akeel |
author_facet | Altalebi, Raghid Reyadh Al-hussaniy, Hany Akeel Al-tameemi, Zahraa Salam AL-Zobaidy, Mohammed Abdul-Hassan Albu-Rghaif, Ali Hikmat Alkuraishy, Hayder Mutter Hedeab, Gomaa Mostafa Azam, Faizul Al-Samydai, Ali Mahmoud Naji, Meena Akeel |
author_sort | Altalebi, Raghid Reyadh |
collection | PubMed |
description | The prevalence of juvenile obesity is increasing, reaching epidemic proportions, presenting a link not only to NAFLD (non-alcoholic fatty liver disease) but to abnormal lipid profiles and liver enzyme abnormalities. Liver ultrasonography is a sensitive and specific tool for the recognition of NAFLD. This study aims to assess the association between NAFLD and juvenile obesity and to determine the other related changes in a set of indicators, including lipid profile abnormalities and serum transaminases. The sample included 470 obese and 210 non-obese individuals aged 6–16. Anthropometric measures were assessed, with the serum lipid profile and liver transaminases, and abdominal ultrasonography was used to detect NAFLD. Fatty liver was found in 38% of the obese subjects and none of the non-obese subjects. Within obese subjects, mean body mass index (BMI) and waist circumference increased significantly in patients with NAFLD compared to those without fatty liver. Moreover, LDL (low-density lipoprotein), CHOL (cholesterol), and serum liver enzymes were significantly higher in the presence of NAFLD. In conclusion, NAFLD commonly associates with juvenile obesity, relating to obesity and the abnormal lipid profile (including elevated CHOL and LDL) among obese people, reflecting elevated liver transaminases, which increase the risk of cirrhosis. |
format | Online Article Text |
id | pubmed-9979179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99791792023-03-03 Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes Altalebi, Raghid Reyadh Al-hussaniy, Hany Akeel Al-tameemi, Zahraa Salam AL-Zobaidy, Mohammed Abdul-Hassan Albu-Rghaif, Ali Hikmat Alkuraishy, Hayder Mutter Hedeab, Gomaa Mostafa Azam, Faizul Al-Samydai, Ali Mahmoud Naji, Meena Akeel J Med Life Original Article The prevalence of juvenile obesity is increasing, reaching epidemic proportions, presenting a link not only to NAFLD (non-alcoholic fatty liver disease) but to abnormal lipid profiles and liver enzyme abnormalities. Liver ultrasonography is a sensitive and specific tool for the recognition of NAFLD. This study aims to assess the association between NAFLD and juvenile obesity and to determine the other related changes in a set of indicators, including lipid profile abnormalities and serum transaminases. The sample included 470 obese and 210 non-obese individuals aged 6–16. Anthropometric measures were assessed, with the serum lipid profile and liver transaminases, and abdominal ultrasonography was used to detect NAFLD. Fatty liver was found in 38% of the obese subjects and none of the non-obese subjects. Within obese subjects, mean body mass index (BMI) and waist circumference increased significantly in patients with NAFLD compared to those without fatty liver. Moreover, LDL (low-density lipoprotein), CHOL (cholesterol), and serum liver enzymes were significantly higher in the presence of NAFLD. In conclusion, NAFLD commonly associates with juvenile obesity, relating to obesity and the abnormal lipid profile (including elevated CHOL and LDL) among obese people, reflecting elevated liver transaminases, which increase the risk of cirrhosis. Carol Davila University Press 2023-01 /pmc/articles/PMC9979179/ /pubmed/36873135 http://dx.doi.org/10.25122/jml-2022-0091 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Altalebi, Raghid Reyadh Al-hussaniy, Hany Akeel Al-tameemi, Zahraa Salam AL-Zobaidy, Mohammed Abdul-Hassan Albu-Rghaif, Ali Hikmat Alkuraishy, Hayder Mutter Hedeab, Gomaa Mostafa Azam, Faizul Al-Samydai, Ali Mahmoud Naji, Meena Akeel Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes |
title | Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes |
title_full | Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes |
title_fullStr | Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes |
title_full_unstemmed | Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes |
title_short | Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes |
title_sort | non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979179/ https://www.ncbi.nlm.nih.gov/pubmed/36873135 http://dx.doi.org/10.25122/jml-2022-0091 |
work_keys_str_mv | AT altalebiraghidreyadh nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT alhussaniyhanyakeel nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT altameemizahraasalam nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT alzobaidymohammedabdulhassan nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT alburghaifalihikmat nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT alkuraishyhaydermutter nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT hedeabgomaamostafa nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT azamfaizul nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT alsamydaialimahmoud nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes AT najimeenaakeel nonalcoholicfattyliverdiseaserelationtojuvenileobesitylipidprofileandhepaticenzymes |