Breast cancer relapses considering molecular biological characteristics

We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual f...

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Detalles Bibliográficos
Autores principales: Smolanka, Ivan Ivanovich, Movchan, Oleksii Volodimirovich, Bagmut, Irina Yuriivna, Sheremet, Michael Ivanovich, Kolisnyk, Igor Leonidovich, Dosenko, Irina Viktorivna, Lyashcnko, Andriy Oleksandrovich, Ivankova, Oksana Mykolaivna, Loboda, Anton Dmitrovich, Shidlovskyi, Oleksandr Viktorovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979183/
https://www.ncbi.nlm.nih.gov/pubmed/36873133
http://dx.doi.org/10.25122/jml-2022-0189
Descripción
Sumario:We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.

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