Breast cancer relapses considering molecular biological characteristics

We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual f...

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Autores principales: Smolanka, Ivan Ivanovich, Movchan, Oleksii Volodimirovich, Bagmut, Irina Yuriivna, Sheremet, Michael Ivanovich, Kolisnyk, Igor Leonidovich, Dosenko, Irina Viktorivna, Lyashcnko, Andriy Oleksandrovich, Ivankova, Oksana Mykolaivna, Loboda, Anton Dmitrovich, Shidlovskyi, Oleksandr Viktorovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979183/
https://www.ncbi.nlm.nih.gov/pubmed/36873133
http://dx.doi.org/10.25122/jml-2022-0189
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author Smolanka, Ivan Ivanovich
Movchan, Oleksii Volodimirovich
Bagmut, Irina Yuriivna
Sheremet, Michael Ivanovich
Kolisnyk, Igor Leonidovich
Dosenko, Irina Viktorivna
Lyashcnko, Andriy Oleksandrovich
Ivankova, Oksana Mykolaivna
Loboda, Anton Dmitrovich
Shidlovskyi, Oleksandr Viktorovich
author_facet Smolanka, Ivan Ivanovich
Movchan, Oleksii Volodimirovich
Bagmut, Irina Yuriivna
Sheremet, Michael Ivanovich
Kolisnyk, Igor Leonidovich
Dosenko, Irina Viktorivna
Lyashcnko, Andriy Oleksandrovich
Ivankova, Oksana Mykolaivna
Loboda, Anton Dmitrovich
Shidlovskyi, Oleksandr Viktorovich
author_sort Smolanka, Ivan Ivanovich
collection PubMed
description We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.
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spelling pubmed-99791832023-03-03 Breast cancer relapses considering molecular biological characteristics Smolanka, Ivan Ivanovich Movchan, Oleksii Volodimirovich Bagmut, Irina Yuriivna Sheremet, Michael Ivanovich Kolisnyk, Igor Leonidovich Dosenko, Irina Viktorivna Lyashcnko, Andriy Oleksandrovich Ivankova, Oksana Mykolaivna Loboda, Anton Dmitrovich Shidlovskyi, Oleksandr Viktorovich J Med Life Original Article We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype. Carol Davila University Press 2023-01 /pmc/articles/PMC9979183/ /pubmed/36873133 http://dx.doi.org/10.25122/jml-2022-0189 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Smolanka, Ivan Ivanovich
Movchan, Oleksii Volodimirovich
Bagmut, Irina Yuriivna
Sheremet, Michael Ivanovich
Kolisnyk, Igor Leonidovich
Dosenko, Irina Viktorivna
Lyashcnko, Andriy Oleksandrovich
Ivankova, Oksana Mykolaivna
Loboda, Anton Dmitrovich
Shidlovskyi, Oleksandr Viktorovich
Breast cancer relapses considering molecular biological characteristics
title Breast cancer relapses considering molecular biological characteristics
title_full Breast cancer relapses considering molecular biological characteristics
title_fullStr Breast cancer relapses considering molecular biological characteristics
title_full_unstemmed Breast cancer relapses considering molecular biological characteristics
title_short Breast cancer relapses considering molecular biological characteristics
title_sort breast cancer relapses considering molecular biological characteristics
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979183/
https://www.ncbi.nlm.nih.gov/pubmed/36873133
http://dx.doi.org/10.25122/jml-2022-0189
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