Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia

Hepatic cholesterol accumulation is an important contributor to hypercholesterolemia, which results in atherosclerosis and cardiovascular disease (CVD). ATP-citrate lyase (ACLY) is a key lipogenic enzyme that converts cytosolic citrate derived from tricarboxylic acid cycle (TCA cycle) to acetyl-CoA...

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Detalles Bibliográficos
Autores principales: Xie, Zhifu, Zhang, Mei, Song, Qian, Cheng, Long, Zhang, Xinwen, Song, Gaolei, Sun, Xinyu, Gu, Min, Zhou, Chendong, Zhang, Yangming, Zhu, Kexin, Yin, Jianpeng, Chen, Xiaoyan, Li, Jingya, Nan, Fajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979192/
https://www.ncbi.nlm.nih.gov/pubmed/36873173
http://dx.doi.org/10.1016/j.apsb.2022.06.011

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