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Neuroprotective Effect of Barbaloin on Streptozotocin-Induced Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB
[Image: see text] Streptozotocin (STZ) impairs memory in rats through altering the central nervous systems (CNS) as a result of impaired cholinergic dysfunction, oxidative stress, persistent hyperglycemia, and alterations in the glucagon-like peptide (GLP). In this model cholinergic agonist, antioxi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979232/ https://www.ncbi.nlm.nih.gov/pubmed/36872976 http://dx.doi.org/10.1021/acsomega.2c08277 |
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author | Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Patil, Shaktipal AlGhamdi, Shareefa A. Alghamdi, Amira M. Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran |
author_facet | Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Patil, Shaktipal AlGhamdi, Shareefa A. Alghamdi, Amira M. Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran |
author_sort | Omer, Asma B. |
collection | PubMed |
description | [Image: see text] Streptozotocin (STZ) impairs memory in rats through altering the central nervous systems (CNS) as a result of impaired cholinergic dysfunction, oxidative stress, persistent hyperglycemia, and alterations in the glucagon-like peptide (GLP). In this model cholinergic agonist, antioxidant and antihyperglycemic treatment has been shown to have positive effects. Barbaloin has a variety of pharmacological effects. However, there is no evidence on how barbaloin improves memory dysfunction caused by STZ. Thus, we examined its effectiveness against cognitive damage caused by STZ at a dose of 60 mg/kg i.p. in Wistar rats. Blood glucose levels (BGL) and body weight (BW) were assessed. To assess learning and memory skills, the Y-maze test and Morris water maze (MWM) test were utilized. Superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), and glutathione (GSH) as oxidative stress markers were regulated to reverse the cognitive deterioration, and choline-acetyltransferase (ChAT) and acetyl-cholinesterase (AChE) as indicators of cholinergic dysfunction, nuclear factor kappa-B (NF-κB), IL-1β (interleukin-1β), IL-6, and tumor necrosis factor-α (TNF-α) contents were used. Barbaloin treatment thereby significantly decreased the BW and learning and memory capacities, resulting in substantial behavioral improvement in the Y-maze and MWM test. BGL, SOD, CAT, MDA, GSH, AChE, ChAT, NF-κB, IL-6, TNF-α, and IL-1β levels were also altered. In conclusion, the findings revealed that barbaloin had a protective impact against cognitive dysfunction caused by STZ. |
format | Online Article Text |
id | pubmed-9979232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99792322023-03-03 Neuroprotective Effect of Barbaloin on Streptozotocin-Induced Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Patil, Shaktipal AlGhamdi, Shareefa A. Alghamdi, Amira M. Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran ACS Omega [Image: see text] Streptozotocin (STZ) impairs memory in rats through altering the central nervous systems (CNS) as a result of impaired cholinergic dysfunction, oxidative stress, persistent hyperglycemia, and alterations in the glucagon-like peptide (GLP). In this model cholinergic agonist, antioxidant and antihyperglycemic treatment has been shown to have positive effects. Barbaloin has a variety of pharmacological effects. However, there is no evidence on how barbaloin improves memory dysfunction caused by STZ. Thus, we examined its effectiveness against cognitive damage caused by STZ at a dose of 60 mg/kg i.p. in Wistar rats. Blood glucose levels (BGL) and body weight (BW) were assessed. To assess learning and memory skills, the Y-maze test and Morris water maze (MWM) test were utilized. Superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), and glutathione (GSH) as oxidative stress markers were regulated to reverse the cognitive deterioration, and choline-acetyltransferase (ChAT) and acetyl-cholinesterase (AChE) as indicators of cholinergic dysfunction, nuclear factor kappa-B (NF-κB), IL-1β (interleukin-1β), IL-6, and tumor necrosis factor-α (TNF-α) contents were used. Barbaloin treatment thereby significantly decreased the BW and learning and memory capacities, resulting in substantial behavioral improvement in the Y-maze and MWM test. BGL, SOD, CAT, MDA, GSH, AChE, ChAT, NF-κB, IL-6, TNF-α, and IL-1β levels were also altered. In conclusion, the findings revealed that barbaloin had a protective impact against cognitive dysfunction caused by STZ. American Chemical Society 2023-02-16 /pmc/articles/PMC9979232/ /pubmed/36872976 http://dx.doi.org/10.1021/acsomega.2c08277 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Patil, Shaktipal AlGhamdi, Shareefa A. Alghamdi, Amira M. Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran Neuroprotective Effect of Barbaloin on Streptozotocin-Induced Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB |
title | Neuroprotective
Effect of Barbaloin on Streptozotocin-Induced
Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory
Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB |
title_full | Neuroprotective
Effect of Barbaloin on Streptozotocin-Induced
Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory
Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB |
title_fullStr | Neuroprotective
Effect of Barbaloin on Streptozotocin-Induced
Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory
Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB |
title_full_unstemmed | Neuroprotective
Effect of Barbaloin on Streptozotocin-Induced
Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory
Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB |
title_short | Neuroprotective
Effect of Barbaloin on Streptozotocin-Induced
Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory
Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB |
title_sort | neuroprotective
effect of barbaloin on streptozotocin-induced
cognitive dysfunction in rats via inhibiting cholinergic and neuroinflammatory
cytokines pathway—tnf-α/il-1β/il-6/nf-κb |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979232/ https://www.ncbi.nlm.nih.gov/pubmed/36872976 http://dx.doi.org/10.1021/acsomega.2c08277 |
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