Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report

BACKGROUND: The incidence of Langerhans cell histiocytosis (LCH) is low, and involvement of the thyroid is even rarer, which results in high missed diagnosis or misdiagnosis rates. CASE SUMMARY: We report a young woman with a thyroid nodule. Thyroid malignancy was suggested by fine needle aspiration...

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Autores principales: Shi, Jing-Jing, Peng, You, Zhang, Yu, Zhou, Li, Pan, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979281/
https://www.ncbi.nlm.nih.gov/pubmed/36874420
http://dx.doi.org/10.12998/wjcc.v11.i5.1152
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author Shi, Jing-Jing
Peng, You
Zhang, Yu
Zhou, Li
Pan, Gang
author_facet Shi, Jing-Jing
Peng, You
Zhang, Yu
Zhou, Li
Pan, Gang
author_sort Shi, Jing-Jing
collection PubMed
description BACKGROUND: The incidence of Langerhans cell histiocytosis (LCH) is low, and involvement of the thyroid is even rarer, which results in high missed diagnosis or misdiagnosis rates. CASE SUMMARY: We report a young woman with a thyroid nodule. Thyroid malignancy was suggested by fine needle aspiration, but she was eventually diagnosed with multisystem LCH, thus avoiding thyroidectomy. CONCLUSION: The clinical manifestations of LCH involving the thyroid are atypical, and the diagnosis depends on pathology. Surgery is the main method for treating primary thyroid LCH, while chemotherapy is the main treatment method for multisystem LCH.
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spelling pubmed-99792812023-03-03 Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report Shi, Jing-Jing Peng, You Zhang, Yu Zhou, Li Pan, Gang World J Clin Cases Case Report BACKGROUND: The incidence of Langerhans cell histiocytosis (LCH) is low, and involvement of the thyroid is even rarer, which results in high missed diagnosis or misdiagnosis rates. CASE SUMMARY: We report a young woman with a thyroid nodule. Thyroid malignancy was suggested by fine needle aspiration, but she was eventually diagnosed with multisystem LCH, thus avoiding thyroidectomy. CONCLUSION: The clinical manifestations of LCH involving the thyroid are atypical, and the diagnosis depends on pathology. Surgery is the main method for treating primary thyroid LCH, while chemotherapy is the main treatment method for multisystem LCH. Baishideng Publishing Group Inc 2023-02-16 2023-02-16 /pmc/articles/PMC9979281/ /pubmed/36874420 http://dx.doi.org/10.12998/wjcc.v11.i5.1152 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Shi, Jing-Jing
Peng, You
Zhang, Yu
Zhou, Li
Pan, Gang
Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report
title Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report
title_full Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report
title_fullStr Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report
title_full_unstemmed Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report
title_short Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report
title_sort langerhans cell histiocytosis misdiagnosed as thyroid malignancy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979281/
https://www.ncbi.nlm.nih.gov/pubmed/36874420
http://dx.doi.org/10.12998/wjcc.v11.i5.1152
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