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Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes

BACKGROUND: Lacunes are the manifestations of lacunar infarction which can lead many patients to the clinical outcome of disability or dementia. However, the relationship between lacune burden, cognitive function and blood glucose fluctuation in patients with type 2 diabetes mellitus (T2DM) complica...

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Autores principales: Meng, Qi-Zhe, Wang, Yang, Li, Bing, Xi, Zhi, Wang, Ming, Xiu, Jia-Qi, Yang, Xiao-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979288/
https://www.ncbi.nlm.nih.gov/pubmed/36874411
http://dx.doi.org/10.12998/wjcc.v11.i5.1019
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author Meng, Qi-Zhe
Wang, Yang
Li, Bing
Xi, Zhi
Wang, Ming
Xiu, Jia-Qi
Yang, Xiao-Peng
author_facet Meng, Qi-Zhe
Wang, Yang
Li, Bing
Xi, Zhi
Wang, Ming
Xiu, Jia-Qi
Yang, Xiao-Peng
author_sort Meng, Qi-Zhe
collection PubMed
description BACKGROUND: Lacunes are the manifestations of lacunar infarction which can lead many patients to the clinical outcome of disability or dementia. However, the relationship between lacune burden, cognitive function and blood glucose fluctuation in patients with type 2 diabetes mellitus (T2DM) complicated with lacunes is not very clear. AIM: To explore the correlation between glucose variability, lacune burden and cognitive function in patients with lacunes complicated with T2DM. METHODS: The clinical and imaging data of 144 patients with lacunes combined with T2DM were reviewed retrospectively. 72 h continuous glucose monitoring was performed. The Montreal Cognitive Assessment was used to assess cognitive function. The burden of lacunes was evaluated using magnetic resonance imaging performance. Multifactorial logistic regression analysis was used to study the affecting the lacune load and cognitive impairment in patients. To predict the value of patients' cognitive impairment with lacunes complicated with T2DM, a receiver operating characteristic (ROC) curve and a nomogram prediction model were constructed. RESULTS: The standard deviation (SD) of the average blood glucose concentration, percentage coefficient of variation (%CV) and time of range (TIR) were significantly different between the low and the high load groups (P < 0.05). The SD, %CV and TIR of the cognitive impairment group and non-cognitive impairment group were significantly different (P < 0.05). SD (odds ratio (OR): 3.558, 95% confidence interval (CI): 1.268-9.978, P = 0.006), and %CV (OR: 1.192, 95%CI: 1.081-1.315, P < 0.05) were the risk factors for an increased infarct burden in lacunes patients complicated with T2DM. TIR (OR: 0.874, 95%CI: 0.833-0.928, P < 0.05) is a protective factor. In addition, an increased SD (OR: 2.506, 95%CI: 1.008-6.23, P = 0.003), %CV (OR: 1.163, 95%CI: 1.065-1.270, P < 0.05) were the risk factors for cognitive impairment in patients with lacunes complicated with T2DM, TIR (OR: 0.957, 95%CI: 0.922-0.994, P < 0.05) is a protective factor. A nomogram prediction model of the risk of cognitive impairment was established based on SD, %CV and TIR. Decision curve analysis and the internal calibration analysis were used for internal verification and showed that the model was clinical benefit. The area under the ROC curves for predicting cognitive impairment in patients with lacunes complicated with T2DM was drawn were %CV: 0.757 (95%CI :0.669-0.845, P < 0.05), TIR: 0.711 (95%CI: 0.623-0.799, P < 0.05). CONCLUSION: Blood glucose variability is closely associated with the level of lacune burden and cognitive dysfunction in lacune patients combined with T2DM. %CV, TIR have a certain predictive effect in cognitive impairment in lacune patients.
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spelling pubmed-99792882023-03-03 Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes Meng, Qi-Zhe Wang, Yang Li, Bing Xi, Zhi Wang, Ming Xiu, Jia-Qi Yang, Xiao-Peng World J Clin Cases Retrospective Study BACKGROUND: Lacunes are the manifestations of lacunar infarction which can lead many patients to the clinical outcome of disability or dementia. However, the relationship between lacune burden, cognitive function and blood glucose fluctuation in patients with type 2 diabetes mellitus (T2DM) complicated with lacunes is not very clear. AIM: To explore the correlation between glucose variability, lacune burden and cognitive function in patients with lacunes complicated with T2DM. METHODS: The clinical and imaging data of 144 patients with lacunes combined with T2DM were reviewed retrospectively. 72 h continuous glucose monitoring was performed. The Montreal Cognitive Assessment was used to assess cognitive function. The burden of lacunes was evaluated using magnetic resonance imaging performance. Multifactorial logistic regression analysis was used to study the affecting the lacune load and cognitive impairment in patients. To predict the value of patients' cognitive impairment with lacunes complicated with T2DM, a receiver operating characteristic (ROC) curve and a nomogram prediction model were constructed. RESULTS: The standard deviation (SD) of the average blood glucose concentration, percentage coefficient of variation (%CV) and time of range (TIR) were significantly different between the low and the high load groups (P < 0.05). The SD, %CV and TIR of the cognitive impairment group and non-cognitive impairment group were significantly different (P < 0.05). SD (odds ratio (OR): 3.558, 95% confidence interval (CI): 1.268-9.978, P = 0.006), and %CV (OR: 1.192, 95%CI: 1.081-1.315, P < 0.05) were the risk factors for an increased infarct burden in lacunes patients complicated with T2DM. TIR (OR: 0.874, 95%CI: 0.833-0.928, P < 0.05) is a protective factor. In addition, an increased SD (OR: 2.506, 95%CI: 1.008-6.23, P = 0.003), %CV (OR: 1.163, 95%CI: 1.065-1.270, P < 0.05) were the risk factors for cognitive impairment in patients with lacunes complicated with T2DM, TIR (OR: 0.957, 95%CI: 0.922-0.994, P < 0.05) is a protective factor. A nomogram prediction model of the risk of cognitive impairment was established based on SD, %CV and TIR. Decision curve analysis and the internal calibration analysis were used for internal verification and showed that the model was clinical benefit. The area under the ROC curves for predicting cognitive impairment in patients with lacunes complicated with T2DM was drawn were %CV: 0.757 (95%CI :0.669-0.845, P < 0.05), TIR: 0.711 (95%CI: 0.623-0.799, P < 0.05). CONCLUSION: Blood glucose variability is closely associated with the level of lacune burden and cognitive dysfunction in lacune patients combined with T2DM. %CV, TIR have a certain predictive effect in cognitive impairment in lacune patients. Baishideng Publishing Group Inc 2023-02-16 2023-02-16 /pmc/articles/PMC9979288/ /pubmed/36874411 http://dx.doi.org/10.12998/wjcc.v11.i5.1019 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Meng, Qi-Zhe
Wang, Yang
Li, Bing
Xi, Zhi
Wang, Ming
Xiu, Jia-Qi
Yang, Xiao-Peng
Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
title Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
title_full Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
title_fullStr Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
title_full_unstemmed Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
title_short Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
title_sort relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979288/
https://www.ncbi.nlm.nih.gov/pubmed/36874411
http://dx.doi.org/10.12998/wjcc.v11.i5.1019
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