An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1

[Image: see text] In this Review, we have addressed some recent developments in the discovery and applications of anti-human immunodeficiency virus type− 1 (HIV−1) broadly neutralizing antibodies (bnAbs) isolated from infected adults and children. The recent developments in human antibody isolation...

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Autores principales: Kumar, Sanjeev, Singh, Swarandeep, Luthra, Kalpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979333/
https://www.ncbi.nlm.nih.gov/pubmed/36873012
http://dx.doi.org/10.1021/acsomega.2c07933
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author Kumar, Sanjeev
Singh, Swarandeep
Luthra, Kalpana
author_facet Kumar, Sanjeev
Singh, Swarandeep
Luthra, Kalpana
author_sort Kumar, Sanjeev
collection PubMed
description [Image: see text] In this Review, we have addressed some recent developments in the discovery and applications of anti-human immunodeficiency virus type− 1 (HIV−1) broadly neutralizing antibodies (bnAbs) isolated from infected adults and children. The recent developments in human antibody isolation technologies have led to the discovery of several highly potent anti-HIV-1 bnAbs. Herein, we have discussed the characteristics of recently identified bnAbs directed at distinct epitopes of HIV-1, in addition to the existing antibodies, from adults and children and have shed light on the benefits of multispecific HIV-1 bnAbs and their role in the design of polyvalent vaccines.
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spelling pubmed-99793332023-03-03 An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1 Kumar, Sanjeev Singh, Swarandeep Luthra, Kalpana ACS Omega [Image: see text] In this Review, we have addressed some recent developments in the discovery and applications of anti-human immunodeficiency virus type− 1 (HIV−1) broadly neutralizing antibodies (bnAbs) isolated from infected adults and children. The recent developments in human antibody isolation technologies have led to the discovery of several highly potent anti-HIV-1 bnAbs. Herein, we have discussed the characteristics of recently identified bnAbs directed at distinct epitopes of HIV-1, in addition to the existing antibodies, from adults and children and have shed light on the benefits of multispecific HIV-1 bnAbs and their role in the design of polyvalent vaccines. American Chemical Society 2023-02-15 /pmc/articles/PMC9979333/ /pubmed/36873012 http://dx.doi.org/10.1021/acsomega.2c07933 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Kumar, Sanjeev
Singh, Swarandeep
Luthra, Kalpana
An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1
title An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1
title_full An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1
title_fullStr An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1
title_full_unstemmed An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1
title_short An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1
title_sort overview of human anti-hiv-1 neutralizing antibodies against diverse epitopes of hiv-1
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979333/
https://www.ncbi.nlm.nih.gov/pubmed/36873012
http://dx.doi.org/10.1021/acsomega.2c07933
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