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Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease

BACKGROUND: Clonal haematopoiesis of indeterminate potential (CHIP) is a predisposition to haematological malignancy whose relationship with chronic inflammatory diseases, such as cardiovascular diseases, has been highlighted. Here, we aimed to investigate the CHIP emergence rate and its association...

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Autores principales: Park, Jihye, An, Hongyul, Lim, Jiwoo, Park, I Seul, Kim, Mi Hyun, Kim, Ji Hyung, Kim, Seung Won, Koh, Young Il, Lee, Eun Young, Cheon, Jae Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979406/
https://www.ncbi.nlm.nih.gov/pubmed/36864496
http://dx.doi.org/10.1186/s13075-023-03014-w
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author Park, Jihye
An, Hongyul
Lim, Jiwoo
Park, I Seul
Kim, Mi Hyun
Kim, Ji Hyung
Kim, Seung Won
Koh, Young Il
Lee, Eun Young
Cheon, Jae Hee
author_facet Park, Jihye
An, Hongyul
Lim, Jiwoo
Park, I Seul
Kim, Mi Hyun
Kim, Ji Hyung
Kim, Seung Won
Koh, Young Il
Lee, Eun Young
Cheon, Jae Hee
author_sort Park, Jihye
collection PubMed
description BACKGROUND: Clonal haematopoiesis of indeterminate potential (CHIP) is a predisposition to haematological malignancy whose relationship with chronic inflammatory diseases, such as cardiovascular diseases, has been highlighted. Here, we aimed to investigate the CHIP emergence rate and its association with inflammatory markers in Behçet’s disease (BD). METHODS: We performed targeted next-generation sequencing to detect the presence of CHIP using peripheral blood cells from 117 BD patients and 5004 healthy controls between March 2009 and September 2021 and analysed the association between CHIP and inflammatory markers. RESULTS: CHIP was detected in 13.9% of patients in the control group and 11.1% of patients in the BD group, indicating no significant intergroup difference. Among the BD patients of our cohort, five variants (DNMT3A, TET2, ASXL1, STAG2, and IDH2) were detected. DNMT3A mutations were the most common, followed by TET2 mutations. CHIP carriers with BD had a higher serum platelet count, erythrocyte sedimentation rate, and C-reactive protein level; older age; and lower serum albumin level at diagnosis than non-CHIP carriers with BD. However, the significant association between inflammatory markers and CHIP disappeared after the adjustment for various variables, including age. Moreover, CHIP was not an independent risk factor for poor clinical outcomes in patients with BD. CONCLUSIONS: Although BD patients did not have higher CHIP emergence rates than the general population, older age and degree of inflammation in BD were associated with CHIP emergence.
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spelling pubmed-99794062023-03-03 Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease Park, Jihye An, Hongyul Lim, Jiwoo Park, I Seul Kim, Mi Hyun Kim, Ji Hyung Kim, Seung Won Koh, Young Il Lee, Eun Young Cheon, Jae Hee Arthritis Res Ther Research BACKGROUND: Clonal haematopoiesis of indeterminate potential (CHIP) is a predisposition to haematological malignancy whose relationship with chronic inflammatory diseases, such as cardiovascular diseases, has been highlighted. Here, we aimed to investigate the CHIP emergence rate and its association with inflammatory markers in Behçet’s disease (BD). METHODS: We performed targeted next-generation sequencing to detect the presence of CHIP using peripheral blood cells from 117 BD patients and 5004 healthy controls between March 2009 and September 2021 and analysed the association between CHIP and inflammatory markers. RESULTS: CHIP was detected in 13.9% of patients in the control group and 11.1% of patients in the BD group, indicating no significant intergroup difference. Among the BD patients of our cohort, five variants (DNMT3A, TET2, ASXL1, STAG2, and IDH2) were detected. DNMT3A mutations were the most common, followed by TET2 mutations. CHIP carriers with BD had a higher serum platelet count, erythrocyte sedimentation rate, and C-reactive protein level; older age; and lower serum albumin level at diagnosis than non-CHIP carriers with BD. However, the significant association between inflammatory markers and CHIP disappeared after the adjustment for various variables, including age. Moreover, CHIP was not an independent risk factor for poor clinical outcomes in patients with BD. CONCLUSIONS: Although BD patients did not have higher CHIP emergence rates than the general population, older age and degree of inflammation in BD were associated with CHIP emergence. BioMed Central 2023-03-02 2023 /pmc/articles/PMC9979406/ /pubmed/36864496 http://dx.doi.org/10.1186/s13075-023-03014-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Park, Jihye
An, Hongyul
Lim, Jiwoo
Park, I Seul
Kim, Mi Hyun
Kim, Ji Hyung
Kim, Seung Won
Koh, Young Il
Lee, Eun Young
Cheon, Jae Hee
Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
title Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
title_full Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
title_fullStr Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
title_full_unstemmed Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
title_short Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
title_sort interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in behçet’s disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979406/
https://www.ncbi.nlm.nih.gov/pubmed/36864496
http://dx.doi.org/10.1186/s13075-023-03014-w
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